普萘洛尔和阿替洛尔导致的β受体阻滞剂过量。

Beta blocker overdose with propranolol and with atenolol.

作者信息

Weinstein R S, Cole S, Knaster H B, Dahlbert T

出版信息

Ann Emerg Med. 1985 Feb;14(2):161-3. doi: 10.1016/s0196-0644(85)81081-7.

Abstract

During a one-month period, two cases of beta-adrenergic blocker overdose were treated by the emergency staff at our hospital. One case of propranolol intoxication demonstrated profound cardiovascular collapse and generalized tonic-clonic seizures. The condition failed to respond to high-dose intravenous pressor agents, but did improve significantly with IV glucagon infusion. The second overdose involved atenolol. Although the blood levels reported were very high, the patient showed no cardiovascular compromise and required only inhaled bronchodilators for an exacerbation of her asthma.

摘要

在一个月的时间里，我院急诊科医护人员治疗了两例β-肾上腺素能阻滞剂过量病例。一例普萘洛尔中毒表现为严重的心血管功能衰竭和全身性强直阵挛性癫痫发作。该病情对大剂量静脉升压药无反应，但静脉输注胰高血糖素后有显著改善。第二例过量服用药物的情况涉及阿替洛尔。尽管报告的血药浓度非常高，但患者未出现心血管功能损害，仅因哮喘加重需要吸入支气管扩张剂治疗。