异烟肼导致感染羊瘙痒病的仓鼠出现癫痫发作，其潜伏期比对照动物短：可能存在γ-氨基丁酸能缺陷。

Isonicotinic hydrazide causes seizures in scrapie-infected hamsters with shorter latency than in control animals: a possible GABAergic defect.

作者信息

Pocchiari M, Masullo C, Lust W D, Gibbs C J, Gajdusek D C

出版信息

Brain Res. 1985 Feb 4;326(1):117-23. doi: 10.1016/0006-8993(85)91390-3.

Abstract

Isonicotinic hydrazide, a drug that decreases the level of GABA, when injected subcutaneously in control and scrapie-infected hamsters induced tonic-clonic seizures in scrapie hamsters significantly earlier (P less than 0.0001) than in control animals. This suggests depression of the GABAergic system in scrapie-infected hamsters. To determine whether this lesion is pre or postsynaptic we measured the level of GABA, glutamate, cGMP and cAMP and the GABA-benzodiazepine receptor complex.

摘要

异烟肼是一种能降低γ-氨基丁酸（GABA）水平的药物，当皮下注射到对照仓鼠和感染羊瘙痒病的仓鼠体内时，感染羊瘙痒病的仓鼠比对照动物显著更早地（P小于0.0001）出现强直阵挛性癫痫发作。这表明感染羊瘙痒病的仓鼠体内γ-氨基丁酸能系统受到抑制。为了确定这种损害是突触前还是突触后的，我们测量了γ-氨基丁酸、谷氨酸、环磷酸鸟苷（cGMP）和环磷酸腺苷（cAMP）的水平以及γ-氨基丁酸-苯二氮䓬受体复合物。