波卡半缩酮A和B，两种来自广藿香的具有前所未有的倍半萜骨架的新型半缩酮。

Pocahemiketals A and B, two new hemiketals with unprecedented sesquiterpenoid skeletons from Pogostemon cablin.

作者信息

Zhu Huan, Zhou Qin-Mei, Peng Cheng, Chen Ming-Hua, Li Xiao-Nian, Lin Da-Sheng, Xiong Liang

机构信息

School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China; State Key Laboratory Breeding Base of Systematic Research, Development and Utilization of Chinese Medicine Resources, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China.

出版信息

Fitoterapia. 2017 Jul;120:67-71. doi: 10.1016/j.fitote.2017.05.013. Epub 2017 May 30.

DOI:10.1016/j.fitote.2017.05.013

PMID:28576720

Abstract

Pocahemiketals A and B (1 and 2), two novel hemiketal sesquiterpenoids with unprecedented skeletons, were isolated from the essential oil of the aerial parts of Pogostemon cablin. In addition to a bicyclo[3.2.1]-carbon core, 1 and 2 possessed a hemiketal α,β-unsaturated-γ-lactone moiety. Their structures were determined by extensive spectroscopic analysis, electronic circular dichroism calculation, and single-crystal X-ray diffraction. Compound 2 exhibited significant vasorelaxant activity against phenylephrine-induced contraction of a rat aorta ring with the EC value of 16.32μM.

摘要

波卡半缩酮A和B（1和2）是从广藿香地上部分的精油中分离得到的两种具有前所未有的骨架的新型半缩酮倍半萜类化合物。除了一个双环[3.2.1]碳核心外，1和2还具有一个半缩酮α,β-不饱和-γ-内酯部分。它们的结构通过广泛的光谱分析、电子圆二色性计算和单晶X射线衍射确定。化合物2对苯肾上腺素诱导的大鼠主动脉环收缩表现出显著的血管舒张活性，其EC值为16.32μM。