Junren Chen, Xiaofang Xie, Mengting Li, Qiuyun Xiong, Gangmin Li, Huiqiong Zhang, Guanru Chen, Xin Xu, Yanpeng Yin, Fu Peng, Cheng Peng
Chengdu University of Traditional Chinese Medicine, Chengdu, 610075, China.
State Key Laboratory of Traditional Chinese Medicine Resources in Southwest China, Chengdu, 610075, China.
Chin Med. 2021 Jan 7;16(1):5. doi: 10.1186/s13020-020-00413-y.
Patchouli ("Guanghuoxiang") or scientifically known as Pogostemon cablin Benth, belonging to the family Lamiaceae, has been used in traditional Chinse medicine (TCM) since the time of the Eastern Han dynasty. In TCM theory, patchouli can treat colds, nausea, fever, headache, and diarrhea. Various bioactive compounds have been identified in patchouli, including terpenoids, phytosterols, flavonoids, organic acids, lignins, glycosides, alcohols, pyrone, and aldehydes. Among the numerous compounds, patchouli alcohol, β-patchoulene, patchoulene epoxide, pogostone, and pachypodol are of great importance. The pharmacological impacts of these compounds include anti-peptic ulcer effect, antimicrobial effect, anti-oxidative effect, anti-inflammatory effect, effect on ischemia/reperfusion injury, analgesic effect, antitumor effect, antidiabetic effect, anti-hypertensive effect, immunoregulatory effect, and others.For this review, we examined publications from the previous five years collected from PubMed, Web of Science, Springer, and the Chinese National Knowledge Infrastructure databases. This review summarizes the recent progress in phytochemistry, pharmacology, and mechanisms of action and provides a reference for future studies focused on clinical applications of this important plant extract.
广藿香（“Guanghuoxiang”），科学名称为 Pogostemon cablin Benth，属于唇形科，自东汉时期以来就已用于传统中医（TCM）。在中医理论中，广藿香可治疗感冒、恶心、发热、头痛和腹泻。广藿香中已鉴定出多种生物活性化合物，包括萜类、植物甾醇、黄酮类、有机酸、木质素、糖苷、醇类、吡喃酮和醛类。在众多化合物中，广藿香醇、β-广藿香烯、广藿香烯环氧化物、广藿香酮和厚壳桂醇尤为重要。这些化合物的药理作用包括抗消化性溃疡作用、抗菌作用、抗氧化作用、抗炎作用、对缺血/再灌注损伤的作用、镇痛作用、抗肿瘤作用、抗糖尿病作用、抗高血压作用、免疫调节作用等。在本次综述中，我们查阅了从 PubMed、科学网、施普林格和中国国家知识基础设施数据库收集的过去五年的出版物。本综述总结了植物化学、药理学及作用机制方面的最新进展，并为今后专注于这种重要植物提取物临床应用的研究提供参考。
