Department of Radiology, First Affiliated Hospital, Guangxi University of Chinese Medicine, Guangxi, P.R. China.
Department of Acupuncture, First Affiliated Hospital, Guangxi University of Chinese Medicine, Guangxi, P.R. China.
J Magn Reson Imaging. 2018 Feb;47(2):545-553. doi: 10.1002/jmri.25775. Epub 2017 Jun 3.
To investigate differences in hippocampal activity between premenstrual syndrome (PMS) patients and healthy controls, to elucidate the neural mechanisms of PMS.
Twenty female patients with PMS (PMS group) and 21 healthy controls (HC group) underwent a single-shot gradient-recalled echo planar imaging (EPI) sequence scan during the luteal phase in 3.0 Tesla MRI. Spontaneous neural activity in hippocampus (HIPP) was measured by fractional amplitude of low-frequency fluctuation (fALFF). Functional connectivity (FC) was used to examine the neural networks of PMS patients by selecting the abnormal HIPP as the seed region. All participants completed a daily record of severity of problems (DRSP) questionnaire to measure the severity of clinical symptoms.
Results from a two-sample t-test showed increased left HIPP fALFF in the PMS group compared with the HC group (P = 0.042), while there was no between-group difference of fALFF in the right HIPP (P = 0.1011). A secondary analysis using a two-sample t-test with the left HIPP as the seed region, the results revealed that the PMS group exhibited increased FC between the left HIPP and left medial prefrontal cortex (mPFC), left posterior cingulate cortex (PCC), right middle cingulate cortex (MCC), and bilateral precentral cortex (PC), while decreased FC between the left HIPP and right orbitofrontal cortex (OFC). Moreover, the PMS group exhibited higher DRSP scores, which were positively correlated (r = 0.64, P = 0.003) with FC between the left HIPP and mPFC during the luteal phase.
Altered spontaneous neural activity and connectivity of left HIPP may be involved in PMS.
1 Technical Efficacy: Stage 2 J. Magn. Reson. Imaging 2018;47:545-553.
探究经前期综合征（PMS）患者与健康对照者之间海马区活动的差异，以阐明 PMS 的神经机制。
在 3.0T MRI 中，20 名经前期综合征（PMS）患者（PMS 组）和 21 名健康对照者（HC 组）在黄体期接受单次梯度回波平面成像（EPI）序列扫描。采用低频波动分数振幅（fALFF）测量海马区（HIPP）的自发神经活动。通过选择异常 HIPP 作为种子区域，采用功能连接（FC）来检测 PMS 患者的神经网络。所有参与者完成严重问题日常记录（DRSP）问卷以测量临床症状的严重程度。
两组间 t 检验结果显示，PMS 组左侧 HIPP 的 fALFF 高于 HC 组（P = 0.042），而右侧 HIPP 的 fALFF 无组间差异（P = 0.1011）。采用以左侧 HIPP 为种子区的两组间 t 检验进行二次分析，结果显示 PMS 组左侧 HIPP 与左侧内侧前额叶皮质（mPFC）、左侧后扣带回皮质（PCC）、右侧中扣带回皮质（MCC）和双侧中央前回（PC）之间的 FC 增加，而与右侧眶额皮质（OFC）之间的 FC 降低。此外，PMS 组的 DRSP 评分较高，且在黄体期左侧 HIPP 与 mPFC 之间的 FC 与 DRSP 评分呈正相关（r = 0.64，P = 0.003）。
左侧 HIPP 的自发神经活动和连接改变可能与 PMS 有关。
1 技术效果：2 级。磁共振成像杂志 2018；47：545-553。
