Krebs Georgina, Fernández de la Cruz Lorena, Monzani Benedetta, Bowyer Laura, Anson Martin, Cadman Jacinda, Heyman Isobel, Turner Cynthia, Veale David, Mataix-Cols David
South London and Maudsley NHS Foundation Trust; Institute of Psychiatry, Psychology and Neuroscience, King's College London.
Karolinska Institutet.
Behav Ther. 2017 Jul;48(4):462-473. doi: 10.1016/j.beth.2017.01.001. Epub 2017 Jan 10.
Emerging evidence suggests that cognitive-behavioral therapy (CBT) is an efficacious treatment for adolescent body dysmorphic disorder (BDD) in the short term, but longer-term outcomes remain unknown. The current study aimed to follow up a group of adolescents who had originally participated in a randomized controlled trial of CBT for BDD to determine whether treatment gains were maintained. Twenty-six adolescents (mean age = 16.2, SD = 1.6) with a primary diagnosis of BDD received a course of developmentally tailored CBT and were followed up over 12 months. Participants were assessed at baseline, midtreatment, posttreatment, 2-, 6-, and 12-month follow-up. The primary outcome measure was the clinician-rated Yale-Brown Obsessive-Compulsive Scale Modified for BDD. Secondary outcomes included measures of insight, depression, quality of life, and global functioning. BDD symptoms decreased significantly from pre- to posttreatment and remained stable over the 12-month follow-up. At this time point, 50% of participants were classified as responders and 23% as remitters. Participants remained significantly improved on all secondary outcomes at 12-month follow-up. Neither baseline insight nor baseline depression predicted long-term outcomes. The positive effects of CBT appear to be durable up to 12-month follow-up. However, the majority of patients remained symptomatic and vulnerable to a range of risks at 12-month follow-up, indicating that longer-term monitoring is advisable in this population. Future research should focus on enhancing the efficacy of CBT in order to improve long-term outcomes.
新出现的证据表明,认知行为疗法(CBT)在短期内是治疗青少年身体变形障碍(BDD)的有效方法,但长期疗效尚不清楚。当前的研究旨在对一组最初参与BDD的CBT随机对照试验的青少年进行随访,以确定治疗效果是否能够维持。26名初步诊断为BDD的青少年(平均年龄 = 16.2,标准差 = 1.6)接受了一个根据发育情况量身定制的CBT疗程,并进行了为期12个月的随访。在基线、治疗中期、治疗后、2个月、6个月和12个月随访时对参与者进行评估。主要结局指标是临床医生评定的针对BDD修改后的耶鲁-布朗强迫症量表。次要结局包括领悟力、抑郁、生活质量和整体功能的测量指标。BDD症状从治疗前到治疗后显著下降,并在12个月的随访中保持稳定。在这个时间点,50%的参与者被归类为有反应者,23%为缓解者。在12个月随访时,参与者在所有次要结局方面仍有显著改善。基线领悟力和基线抑郁均不能预测长期结局。CBT的积极效果在长达12个月的随访中似乎是持久的。然而,在12个月随访时,大多数患者仍有症状,且易受一系列风险影响,这表明对该人群进行长期监测是可取的。未来的研究应侧重于提高CBT的疗效,以改善长期结局。