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躯体变形障碍的模块化认知行为疗法:一项随机对照试验。

Modular cognitive-behavioral therapy for body dysmorphic disorder: a randomized controlled trial.

作者信息

Wilhelm Sabine, Phillips Katharine A, Didie Elizabeth, Buhlmann Ulrike, Greenberg Jennifer L, Fama Jeanne M, Keshaviah Aparna, Steketee Gail

机构信息

Massachusetts General Hospital and Harvard Medical School.

Rhode Island Hospital and Alpert Medical School of Brown University.

出版信息

Behav Ther. 2014 May;45(3):314-27. doi: 10.1016/j.beth.2013.12.007. Epub 2013 Dec 29.

Abstract

There are few effective treatments for body dysmorphic disorder (BDD) and a pressing need to develop such treatments. We examined the feasibility, acceptability, and efficacy of a manualized modular cognitive-behavioral therapy for BDD (CBT-BDD). CBT-BDD utilizes core elements relevant to all BDD patients (e.g., exposure, response prevention, perceptual retraining) and optional modules to address specific symptoms (e.g., surgery seeking). Thirty-six adults with BDD were randomized to 22 sessions of immediate individual CBT-BDD over 24 weeks (n=17) or to a 12-week waitlist (n=19). The Yale-Brown Obsessive-Compulsive Scale Modified for BDD (BDD-YBOCS), Brown Assessment of Beliefs Scale, and Beck Depression Inventory-II were completed pretreatment, monthly, posttreatment, and at 3- and 6-month follow-up. The Sheehan Disability Scale and Client Satisfaction Inventory (CSI) were also administered. Response to treatment was defined as ≥30% reduction in BDD-YBOCS total from baseline. By week 12, 50% of participants receiving immediate CBT-BDD achieved response versus 12% of waitlisted participants (p=0.026). By posttreatment, 81% of all participants (immediate CBT-BDD plus waitlisted patients subsequently treated with CBT-BDD) met responder criteria. While no significant group differences in BDD symptom reduction emerged by Week 12, by posttreatment CBT-BDD resulted in significant decreases in BDD-YBOCS total over time (d=2.1, p<0.0001), with gains maintained during follow-up. Depression, insight, and disability also significantly improved. Patient satisfaction was high, with a mean CSI score of 87.3% (SD=12.8%) at posttreatment. CBT-BDD appears to be a feasible, acceptable, and efficacious treatment that warrants more rigorous investigation.

摘要

躯体变形障碍(BDD)的有效治疗方法很少,因此迫切需要开发此类治疗方法。我们研究了一种针对BDD的手册化模块化认知行为疗法(CBT-BDD)的可行性、可接受性和疗效。CBT-BDD利用与所有BDD患者相关的核心要素(如暴露、反应预防、感知再训练)以及针对特定症状(如寻求手术)的可选模块。36名患有BDD的成年人被随机分为两组,一组在24周内接受22节即时个体CBT-BDD治疗(n = 17),另一组进入12周的等待名单(n = 19)。在治疗前、每月、治疗后以及3个月和6个月随访时,完成了针对BDD修改的耶鲁-布朗强迫量表(BDD-YBOCS)、布朗信念评估量表和贝克抑郁量表-II。还进行了希恩残疾量表和患者满意度问卷(CSI)的评估。治疗反应定义为BDD-YBOCS总分较基线降低≥30%。到第12周时,接受即时CBT-BDD治疗的参与者中有50%达到反应标准,而等待名单上的参与者中这一比例为12%(p = 0.026)。到治疗后,所有参与者(即时CBT-BDD组加上等待名单上随后接受CBT-BDD治疗的患者)中有81%达到反应标准。虽然在第12周时,两组在BDD症状减轻方面没有显著差异,但到治疗后,CBT-BDD随着时间的推移导致BDD-YBOCS总分显著下降(d = 2.1,p < 0.xxx),随访期间保持了改善。抑郁、洞察力和残疾状况也有显著改善。患者满意度较高,治疗后CSI平均得分为87.3%(标准差 = 12.8%)。CBT-BDD似乎是一种可行、可接受且有效的治疗方法,值得进行更严格的研究。 (注:原文中“p < 0.0001”这里的“xxx”疑似有误,应补充完整具体数字)

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/352b/4283214/76733a80491f/nihms-638415-f0001.jpg

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