• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

在一个由395名镰状细胞贫血患儿组成的新生儿队列中，白细胞介素-10单倍型与急性脑缺血或高危经颅多普勒检查无关。

Interleukin-10 haplotypes are not associated with acute cerebral ischemia or high-risk transcranial Doppler in a newborn cohort of 395 children with sickle cell anemia.

作者信息

Belisário André Rolim, Sales Rahyssa Rodrigues, Toledo Nayara Evelin, Velloso-Rodrigues Cibele, Silva Célia Maria, Viana Marcos Borato

机构信息

Fundação Hemominas, Centro de Tecidos Biológicos de Minas Gerais, Lagoa Santa, MG, Brazil; Universidade Federal de Minas Gerais (UFMG), Faculdade de Medicina, Belo Horizonte, MG, Brazil.

Universidade Federal de Minas Gerais (UFMG), Faculdade de Medicina, Belo Horizonte, MG, Brazil.

出版信息

Rev Bras Hematol Hemoter. 2017 Apr-Jun;39(2):108-114. doi: 10.1016/j.bjhh.2016.09.017. Epub 2017 Feb 21.

DOI:10.1016/j.bjhh.2016.09.017
PMID:28577646
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5457462/
Abstract

BACKGROUND

The etiology of stroke, a severe complication of sickle cell anemia, involves inflammatory processes. However, the pathogenetic mechanisms are unknown. The aim of this study was to evaluate the influence of interleukin-10 polymorphisms and haplotypes on the risk of acute cerebral ischemia and high-risk transcranial Doppler in 395 children with sickle cell anemia from the state of Minas Gerais, Brazil.

METHODS

Interleukin-10 haplotypes were determined by polymerase chain reaction-restriction fragment length polymorphism and sequencing. The outcomes studied were acute cerebral ischemia and high-risk transcranial Doppler. Clinical data were retrieved from the children's records.

RESULTS

There was no statistically significant difference in the frequencies of polymorphisms and haplotypes between children with and without acute cerebral ischemia or children with or without high-risk transcranial Doppler. These data are consistent with a previous report that showed an absence of association between interleukin-10 plasma levels and high-risk transcranial Doppler velocity in children with sickle cell anemia.

CONCLUSION

Interleukin-10 haplotypes were not associated with the risk of acute cerebral ischemia or high-risk transcranial Doppler velocity in children with sickle cell anemia from the state of Minas Gerais, Brazil.

摘要

背景

中风是镰状细胞贫血的一种严重并发症，其病因涉及炎症过程。然而，发病机制尚不清楚。本研究的目的是评估白细胞介素-10基因多态性和单倍型对巴西米纳斯吉拉斯州395例镰状细胞贫血儿童急性脑缺血风险和高风险经颅多普勒的影响。

方法

通过聚合酶链反应-限制性片段长度多态性和测序确定白细胞介素-10单倍型。研究的结果是急性脑缺血和高风险经颅多普勒。临床数据从儿童记录中获取。

结果

有或无急性脑缺血的儿童之间以及有或无高风险经颅多普勒的儿童之间，多态性和单倍型的频率没有统计学上的显著差异。这些数据与之前的一份报告一致，该报告显示镰状细胞贫血儿童的白细胞介素-10血浆水平与高风险经颅多普勒速度之间不存在关联。

结论

在巴西米纳斯吉拉斯州的镰状细胞贫血儿童中，白细胞介素-10单倍型与急性脑缺血风险或高风险经颅多普勒速度无关。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb8d/5457462/ff06ffbdeeb3/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb8d/5457462/64a124c77d8d/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb8d/5457462/ff06ffbdeeb3/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb8d/5457462/64a124c77d8d/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb8d/5457462/ff06ffbdeeb3/gr2.jpg

相似文献

1
Interleukin-10 haplotypes are not associated with acute cerebral ischemia or high-risk transcranial Doppler in a newborn cohort of 395 children with sickle cell anemia.在一个由395名镰状细胞贫血患儿组成的新生儿队列中，白细胞介素-10单倍型与急性脑缺血或高危经颅多普勒检查无关。
Rev Bras Hematol Hemoter. 2017 Apr-Jun;39(2):108-114. doi: 10.1016/j.bjhh.2016.09.017. Epub 2017 Feb 21.
2
Reticulocyte count is the most important predictor of acute cerebral ischemia and high-risk transcranial Doppler in a newborn cohort of 395 children with sickle cell anemia.在一个由395名镰状细胞贫血患儿组成的新生儿队列中，网织红细胞计数是急性脑缺血和高危经颅多普勒检查的最重要预测指标。
Ann Hematol. 2016 Oct;95(11):1869-80. doi: 10.1007/s00277-016-2789-5. Epub 2016 Aug 13.
3
Glucose-6-Phosphate Dehydrogenase Deficiency in Brazilian Children With Sickle Cell Anemia is not Associated With Clinical Ischemic Stroke or High-Risk Transcranial Doppler.巴西镰状细胞贫血患儿的葡萄糖-6-磷酸脱氢酶缺乏与临床缺血性中风或高风险经颅多普勒检查无关。
Pediatr Blood Cancer. 2016 Jun;63(6):1046-9. doi: 10.1002/pbc.25924. Epub 2016 Feb 3.
4
Association of alpha-thalassemia, TNF-alpha (-308G>A) and VCAM-1 (c.1238G>C) gene polymorphisms with cerebrovascular disease in a newborn cohort of 411 children with sickle cell anemia.411名镰状细胞贫血新生儿队列中α-地中海贫血、肿瘤坏死因子-α（-308G>A）和血管细胞黏附分子-1（c.1238G>C）基因多态性与脑血管疾病的关联
Blood Cells Mol Dis. 2015 Jan;54(1):44-50. doi: 10.1016/j.bcmd.2014.08.001. Epub 2014 Aug 27.
5
Prevention of a first stroke by transfusions in children with sickle cell anemia and abnormal results on transcranial Doppler ultrasonography.对镰状细胞贫血且经颅多普勒超声检查结果异常的儿童进行输血以预防首次中风
N Engl J Med. 1998 Jul 2;339(1):5-11. doi: 10.1056/NEJM199807023390102.
6
The Natural History of Hb S/Hereditary Persistence of Fetal Hemoglobin in 13 Children from the State of Minas Gerais, Brazil.巴西米纳斯吉拉斯州13名儿童中血红蛋白S/胎儿血红蛋白遗传性持续存在的自然病史
Hemoglobin. 2016 Jun;40(3):215-9. doi: 10.3109/03630269.2016.1149076. Epub 2016 Mar 22.
7
Transcranial Doppler Ultrasound in Peninsular Arab Patients With Sickle Cell Disease.半岛阿拉伯镰状细胞病患者的经颅多普勒超声检查
J Ultrasound Med. 2019 Jan;38(1):165-172. doi: 10.1002/jum.14680. Epub 2018 May 6.
8
[Study of - maximum systolic velocities and mean maximum velocities of skull base arteries recorded with transcranial Doppler in adult sickle cell patients without neurovascular complication].[对无神经血管并发症的成年镰状细胞病患者经颅多普勒记录的颅底动脉最大收缩期速度和平均最大速度的研究]
J Med Vasc. 2019 Jun;44(4):249-259. doi: 10.1016/j.jdmv.2019.04.008. Epub 2019 May 29.
9
Comparison of transcranial Doppler sonography with and without imaging in the evaluation of children with sickle cell anemia.在镰状细胞贫血患儿评估中经颅多普勒超声成像与非成像检查的比较
AJR Am J Roentgenol. 2004 Oct;183(4):1117-22. doi: 10.2214/ajr.183.4.1831117.
10
Comparison of transcranial color Doppler imaging (TCDI) and transcranial Doppler (TCD) in children with sickle-cell anemia.镰状细胞贫血患儿经颅彩色多普勒成像（TCDI）与经颅多普勒（TCD）的比较。
Pediatr Radiol. 2001 Jul;31(7):461-9. doi: 10.1007/s002470100427.

引用本文的文献

1
IL10 (-1082 G>A, rs1800896) gene polymorphisms are associated with oxidative stress in sickle cell disease patients in Uganda.白细胞介素10（IL10，-1082 G>A，rs1800896）基因多态性与乌干达镰状细胞病患者的氧化应激相关。
Biol Res. 2025 Sep 3;58(1):61. doi: 10.1186/s40659-025-00639-w.
2
Interleukins 10 and 1β gene polymorphisms in ischemic stroke risk in the Egyptian population.埃及人群中白细胞介素10和1β基因多态性与缺血性中风风险的关系
Sci Rep. 2025 May 14;15(1):16792. doi: 10.1038/s41598-025-98531-w.
3
Genetic Variation and Sickle Cell Disease Severity: A Systematic Review and Meta-Analysis.

本文引用的文献

1
Reticulocyte count is the most important predictor of acute cerebral ischemia and high-risk transcranial Doppler in a newborn cohort of 395 children with sickle cell anemia.在一个由395名镰状细胞贫血患儿组成的新生儿队列中，网织红细胞计数是急性脑缺血和高危经颅多普勒检查的最重要预测指标。
Ann Hematol. 2016 Oct;95(11):1869-80. doi: 10.1007/s00277-016-2789-5. Epub 2016 Aug 13.
2
Clinical and haematological risk factors for cerebral macrovasculopathy in a sickle cell disease newborn cohort: a prospective study.镰状细胞病新生儿队列中脑大血管病变的临床和血液学危险因素：一项前瞻性研究
Br J Haematol. 2016 Mar;172(6):966-77. doi: 10.1111/bjh.13916. Epub 2016 Jan 5.
3
遗传变异与镰状细胞病严重程度：系统评价和荟萃分析。
JAMA Netw Open. 2023 Oct 2;6(10):e2337484. doi: 10.1001/jamanetworkopen.2023.37484.
Contribution of Reduced Interleukin-10 Levels to the Pathogenesis of Osteomyelitis in Children with Sickle Cell Disease.
白细胞介素-10水平降低对镰状细胞病患儿骨髓炎发病机制的影响
Clin Vaccine Immunol. 2015 Sep;22(9):1020-4. doi: 10.1128/CVI.00286-15. Epub 2015 Jul 1.
4
Serum IL-6, IL-10, and TNFα levels in pediatric sickle cell disease patients during vasoocclusive crisis and steady state condition.小儿镰状细胞病患者在血管闭塞性危象和稳定状态期间的血清白细胞介素-6、白细胞介素-10和肿瘤坏死因子α水平。
Cytokine. 2015 Mar;72(1):43-7. doi: 10.1016/j.cyto.2014.11.030. Epub 2015 Jan 5.
5
Association of interleukin-10 promoter haplotypes with disease susceptibility and IL-10 levels in Mexican patients with systemic lupus erythematosus.白细胞介素-10启动子单倍型与墨西哥系统性红斑狼疮患者疾病易感性及白细胞介素-10水平的关联
Clin Exp Med. 2015 Nov;15(4):439-46. doi: 10.1007/s10238-014-0315-4. Epub 2014 Sep 25.
6
Association of alpha-thalassemia, TNF-alpha (-308G>A) and VCAM-1 (c.1238G>C) gene polymorphisms with cerebrovascular disease in a newborn cohort of 411 children with sickle cell anemia.411名镰状细胞贫血新生儿队列中α-地中海贫血、肿瘤坏死因子-α（-308G>A）和血管细胞黏附分子-1（c.1238G>C）基因多态性与脑血管疾病的关联
Blood Cells Mol Dis. 2015 Jan;54(1):44-50. doi: 10.1016/j.bcmd.2014.08.001. Epub 2014 Aug 27.
7
Interleukin-10 promoter 1082/-819/-592 polymorphisms are associated with asthma susceptibility in Asians and atopic asthma: a meta-analysis.白细胞介素-10 启动子 1082/-819/-592 多态性与亚洲人群哮喘易感性和特应性哮喘相关：一项荟萃分析。
Lung. 2014 Feb;192(1):65-73. doi: 10.1007/s00408-013-9519-8. Epub 2013 Oct 27.
8
Relationship of serum interleukin-10 and its genetic variations with ischemic stroke in a Chinese general population.血清白细胞介素-10 及其遗传变异与中国一般人群缺血性卒中的关系。
PLoS One. 2013 Sep 11;8(9):e74126. doi: 10.1371/journal.pone.0074126. eCollection 2013.
9
Genetic mapping and exome sequencing identify 2 mutations associated with stroke protection in pediatric patients with sickle cell anemia.遗传图谱和外显子组测序鉴定出 2 个突变与镰状细胞贫血儿科患者的中风保护相关。
Blood. 2013 Apr 18;121(16):3237-45. doi: 10.1182/blood-2012-10-464156. Epub 2013 Feb 19.
10
Magnetic resonance angiography-defined intracranial vasculopathy is associated with silent cerebral infarcts and glucose-6-phosphate dehydrogenase mutation in children with sickle cell anaemia.磁共振血管造影定义的颅内血管病变与镰状细胞贫血患儿的无症状性脑梗死和葡萄糖-6-磷酸脱氢酶突变相关。
Br J Haematol. 2012 Nov;159(3):352-9. doi: 10.1111/bjh.12034. Epub 2012 Sep 7.