鲍曼不动杆菌LUH5535和LUH5554的K35和K15荚膜多糖结构，包含氨基糖醛酸和二氨基糖醛酸。
Structures of the K35 and K15 capsular polysaccharides of Acinetobacter baumannii LUH5535 and LUH5554 containing amino and diamino uronic acids.
作者信息
Shashkov Alexander S, Liu Bin, Kenyon Johanna J, Popova Anastasiya V, Shneider Mikhail M, Senchenkova Sof'ya N, Arbatsky Nikolay P, Miroshnikov Konstantin A, Wang Lei, Knirel Yuriy A
机构信息
N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Moscow, Russia.
TEDA School of Biological Sciences and Biotechnology, Nankai University, TEDA, Tianjin, China.
出版信息
Carbohydr Res. 2017 Aug 7;448:28-34. doi: 10.1016/j.carres.2017.05.017. Epub 2017 May 25.
Capsular polysaccharides were isolated from A. baumannii LUH5535 (K35 CPS) and LUH5554 (K15 CPS) and studied by 1D and 2D H and C NMR spectroscopy. The CPSs were found to consist of linear tetrasaccharide repeats (K units) containing 2-acetamido-2-deoxy-d-galacturonic acid (K35) or 2,3-diacetamido-2,3-deoxy-d-glucuronic acid (K15) and 2,4-diacetamido-2,4,6-trideoxy-d-glucose (both CPSs). The K35 unit includes three O-acetyl groups on different GalNAcA residues. A. baumannii LUH5535 and LUH5554 carry the KL35 and KL15 gene clusters, respectively, and putatively assigned functions of genes in these clusters were consistent with the CPS structures established.
从鲍曼不动杆菌LUH5535（K35 CPS）和LUH5554（K15 CPS）中分离出荚膜多糖，并通过一维和二维氢谱及碳谱核磁共振波谱进行研究。发现这些荚膜多糖由线性四糖重复序列（K单元）组成，其中包含2-乙酰氨基-2-脱氧-D-半乳糖醛酸（K35）或2,3-二乙酰氨基-2,3-脱氧-D-葡萄糖醛酸（K15）以及2,4-二乙酰氨基-2,4,6-三脱氧-D-葡萄糖（两种荚膜多糖均含有）。K35单元在不同的N-乙酰半乳糖胺残基上包含三个O-乙酰基。鲍曼不动杆菌LUH5535和LUH5554分别携带KL35和KL15基因簇，这些簇中基因的推定功能与所确定的荚膜多糖结构一致。
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