人α-心房利钠肽对健康志愿者的肾脏、血流动力学及激素的影响

Renal, haemodynamic, and hormonal effects of human alpha atrial natriuretic peptide in healthy volunteers.

作者信息

Richards A M, Nicholls M G, Ikram H, Webster M W, Yandle T G, Espiner E A

出版信息

Lancet. 1985 Mar 9;1(8428):545-9. doi: 10.1016/s0140-6736(85)91207-3.

Abstract

The effects of atrial natriuretic peptide (ANP) were investigated in six healthy male volunteers taking a constant diet (120 mmol sodium and 60 mmol potassium daily). They were given an intravenous bolus of 100 micrograms human alpha-ANP on one day or placebo on another day 1-3 weeks apart in a double-blind randomised study. After ANP, urinary sodium excretion increased four-fold, and urine volume, calcium, magnesium, and phosphorus excretion doubled within 30 min of the injection. ANP induced an immediate fall in arterial pressure, followed by a longer vasodepressor phase which exceeded the duration of the effect on electrolyte excretion. There were no significant changes in plasma renin activity, aldosterone, antidiuretic hormone, or noradrenaline when compared with placebo.

摘要

在六名食用固定饮食（每日120毫摩尔钠和60毫摩尔钾）的健康男性志愿者中研究了心房利钠肽（ANP）的作用。在一项双盲随机研究中，他们在相隔1至3周的某一天接受了100微克人α-ANP的静脉推注，在另一天接受了安慰剂。注射ANP后，尿钠排泄增加了四倍，尿量、钙、镁和磷排泄在注射后30分钟内增加了一倍。ANP导致动脉压立即下降，随后是一个较长的血管减压期，该期超过了对电解质排泄的影响持续时间。与安慰剂相比，血浆肾素活性、醛固酮、抗利尿激素或去甲肾上腺素没有显著变化。