Poser H, Berlanda M, Monacolli M, Contiero B, Coltro A, Guglielmini C
University of Padua, Department of Animal Medicine, Production and Health, Viale dell'Università, 16, 35020, Legnaro PD, Italy.
University of Padua, Department of Animal Medicine, Production and Health, Viale dell'Università, 16, 35020, Legnaro PD, Italy.
J Vet Cardiol. 2017 Jun;19(3):228-239. doi: 10.1016/j.jvc.2017.03.007. Epub 2017 Jun 2.
To evaluate tricuspid annular plane systolic excursion (TAPSE) in dogs with myxomatous mitral valve disease (MMVD) with or without pulmonary hypertension (PH) and to study the correlations with clinical and echocardiographic parameters.
The study population included 99 dogs with MMVD and tricuspid regurgitation.
This is a prospective clinical study. All dogs received a transthoracic echocardiographic evaluation, including 2D, M-mode, echo-Doppler, and tissue Doppler measurements. The TAPSE was measured from the left apical four-chamber view and normalized for the effect of body weight (nTAPSE). The dogs were grouped according to the severity of MMVD (American College of Veterinary Internal Medicine guidelines) and presence/absence and severity of PH. Significant differences between TAPSE or nTAPSE and echocardiographic parameters were analyzed among the MMVD and PH severity groups. Correlations between TAPSE or nTAPSE and echocardiographic parameters were calculated.
Tricuspid annular plane systolic excursion or nTAPSE were not significantly different among dogs of the MMVD or PH severity groups. Significant correlations were obtained between TAPSE and body weight, left ventricular and atrial dimensions, early diastolic septal and early diastolic and systolic tricuspid annulus velocity (p<0.001); nTAPSE was significantly correlated with normalized end-diastolic left ventricular dimension and fractional shortening (p<0.001).
The results show that neither TAPSE nor nTAPSE are reduced in dogs with MMVD with or without PH. It remains unclear if the right ventricle function is not reduced or if a reduced right ventricle function is masked by the contraction of the left ventricle through ventricular interdependence.
评估患有或不患有肺动脉高压（PH）的黏液瘤性二尖瓣疾病（MMVD）犬的三尖瓣环平面收缩期位移（TAPSE），并研究其与临床和超声心动图参数的相关性。
研究群体包括99只患有MMVD和三尖瓣反流的犬。
这是一项前瞻性临床研究。所有犬均接受经胸超声心动图评估，包括二维、M型、回声多普勒和组织多普勒测量。从左心尖四腔心视图测量TAPSE，并对体重影响进行标准化（nTAPSE）。根据MMVD的严重程度（美国兽医内科学会指南）以及PH的存在与否和严重程度对犬进行分组。分析MMVD和PH严重程度组之间TAPSE或nTAPSE与超声心动图参数的显著差异。计算TAPSE或nTAPSE与超声心动图参数之间的相关性。
MMVD或PH严重程度组的犬之间，三尖瓣环平面收缩期位移或nTAPSE无显著差异。TAPSE与体重、左心室和心房尺寸、舒张早期室间隔以及舒张早期和收缩期三尖瓣环速度之间存在显著相关性（p<0.001）；nTAPSE与标准化舒张末期左心室尺寸和缩短分数显著相关（p<0.001）。
结果表明，患有或不患有PH的MMVD犬的TAPSE和nTAPSE均未降低。尚不清楚右心室功能是否未降低，或者右心室功能降低是否被左心室通过心室相互依存的收缩所掩盖。
