维生素D与慢性疾病。
Vitamin D and Chronic Diseases.
作者信息
Wang Hanmin, Chen Weiwen, Li Dongqing, Yin Xiaoe, Zhang Xiaode, Olsen Nancy, Zheng Song Guo
机构信息
1Division of Endocrinology, Quqing First Hospital at Kunming Medical University, Qujing, Yunan 655400, China.
2Expert Workstation, Quqing First Hospital at Kunming Medical University, Qujing, Yunan 655400, China.
出版信息
Aging Dis. 2017 May 2;8(3):346-353. doi: 10.14336/AD.2016.1021. eCollection 2017 May.
Abstract
Vitamin D is one of the essential nutrients to sustain the human health. As a member of the steroid hormone family, it has a classic role in regulating metabolism of calcium and a non-classic role in affecting cell proliferation and differentiation. Epidemiological studies have shown that 25OHD deficiency is closely associated with common chronic diseases such as bone metabolic disorders, tumors, cardiovascular diseases, and diabetes. 25OHD deficiency is also a risk factor for neuropsychiatric disorders and autoimmune diseases. 25OHD deficiency is highly prevalent in the world. It is therefore necessary to know the adverse health effects of 25OHD deficiency, and to design interventions and early treatments for those who are likely to have low levels of 25OHD.
摘要
维生素D是维持人体健康的必需营养素之一。作为类固醇激素家族的一员，它在调节钙代谢方面具有经典作用，在影响细胞增殖和分化方面具有非经典作用。流行病学研究表明，25羟维生素D缺乏与骨代谢紊乱、肿瘤、心血管疾病和糖尿病等常见慢性病密切相关。25羟维生素D缺乏也是神经精神疾病和自身免疫性疾病的一个危险因素。25羟维生素D缺乏在世界范围内高度流行。因此，有必要了解25羟维生素D缺乏对健康的不良影响，并为那些可能25羟维生素D水平较低的人群设计干预措施和早期治疗方法。
相似文献
1
Vitamin D and Chronic Diseases.
Aging Dis. 2017 May 2;8(3):346-353. doi: 10.14336/AD.2016.1021. eCollection 2017 May.
2
Circulating 25OHD, dietary vitamin D, PTH, and calcium associations with incident cardiovascular disease and mortality: the MIDSPAN Family Study.
J Clin Endocrinol Metab. 2012 Dec;97(12):4578-87. doi: 10.1210/jc.2012-2272. Epub 2012 Oct 15.
3
Relationship between serum 25-hydroxyvitamin D and parathyroid hormone in the search for a biochemical definition of vitamin D deficiency in children.
Pediatr Res. 2013 Nov;74(5):552-6. doi: 10.1038/pr.2013.139. Epub 2013 Sep 2.
4
Risk factors for vitamin D deficiency in breast-fed newborns and their mothers.
Nutrition. 2002 Jan;18(1):47-50. doi: 10.1016/s0899-9007(01)00724-9.
5
Vitamin D status and PTH in young men: a cross-sectional study on associations with bone mineral density, body composition and glucose metabolism.
Clin Endocrinol (Oxf). 2010 Nov;73(5):573-80. doi: 10.1111/j.1365-2265.2010.03847.x.
6
Relationship between 25-hydroxyvitamin D concentrations, serum calcium, and parathyroid hormone in apparently healthy Syrian people.
Arch Osteoporos. 2014;9:176. doi: 10.1007/s11657-014-0176-1. Epub 2014 Apr 9.
7
Low 25-Hydroxyvitamin D in Primary Hyperparathyroidism: Enhanced Conversion Into 1,25-Hydroxyvitamin D May Not Be "True" Deficiency.
JBMR Plus. 2020 Oct 18;4(11):e10415. doi: 10.1002/jbm4.10415. eCollection 2020 Nov.
8
Threshold Effects of Vitamin D Status on Bone Health in Chinese Adolescents With Low Calcium Intake.
J Clin Endocrinol Metab. 2015 Dec;100(12):4481-9. doi: 10.1210/jc.2015-2849. Epub 2015 Oct 14.
9
Vitamin D deficiency in HIV infection: an underestimated and undertreated epidemic.
Eur Rev Med Pharmacol Sci. 2013 May;17(9):1218-32.
10
Vitamin D status, seasonal variations, parathyroid adenoma weight and bone mineral density in primary hyperparathyroidism.
Clin Endocrinol (Oxf). 2005 Nov;63(5):506-13. doi: 10.1111/j.1365-2265.2005.02371.x.
引用本文的文献
1
Investigating effective factors on musculoskeletal pain prevention behaviors in the elderly population living in nursing homes, based on the health belief model: structural equation modeling approach.
BMC Geriatr. 2025 Sep 3;25(1):685. doi: 10.1186/s12877-025-06229-5.
2
Vitamin D's Impact on Cancer Incidence and Mortality: A Systematic Review.
Nutrients. 2025 Jul 16;17(14):2333. doi: 10.3390/nu17142333.
3
Nutri-Epigenetic Regulation of Vitamin D-Impact on Metabolism and Biological Functions: Narrative Review.
Metabolites. 2025 Jun 30;15(7):436. doi: 10.3390/metabo15070436.
4
Factors associated with the serum 25-hydroxyvitamin D levels in adults.
BMC Nutr. 2025 Jul 5;11(1):132. doi: 10.1186/s40795-025-01120-3.
5
Mediating role of inflammatory markers (NLR, PLR, SII, SIRI) in the association between 25(OH)D deficiency and obesity in children and adolescents.
J Health Popul Nutr. 2025 Jun 21;44(1):215. doi: 10.1186/s41043-025-00981-5.
6
Effects of vitamin D supplementation on symptoms and clinical outcomes in adults with different baseline vitamin D levels: an interventional study.
J Health Popul Nutr. 2025 May 29;44(1):176. doi: 10.1186/s41043-025-00881-8.
7
Vitamin D and Colorectal Cancer Prevention: Immunological Mechanisms, Inflammatory Pathways, and Nutritional Implications.
Nutrients. 2025 Apr 15;17(8):1351. doi: 10.3390/nu17081351.
8
Genetic Polymorphisms in Cytochrome P450 Enzymes Involved in Vitamin D Metabolism and the Vitamin D Receptor: Their Clinical Relevance.
J Pers Med. 2025 Mar 27;15(4):128. doi: 10.3390/jpm15040128.
9
Vitamin D alleviates oxidative stress in varicose veins: a pilot study in obese and non-obese patients.
Mol Cell Biochem. 2025 Apr 22. doi: 10.1007/s11010-025-05292-1.
10
Impact of vitamin D deficiency on postoperative outcomes in patients with chronic kidney disease undergoing surgery: a retrospective study.
Sci Rep. 2025 Mar 21;15(1):9757. doi: 10.1038/s41598-025-93807-7.
本文引用的文献
1
The epidemic investigation of serum 25-hydroxy vitamin D levels in the adults in Qujing area of Yunnan province in China.
Int J Clin Exp Pathol. 2015 Aug 1;8(8):9597-601. eCollection 2015.
2
DOES VITAMIN D DEFICIENCY CONTRIBUTE TO THE SEVERITY OF ASTHMA IN CHILDREN AND ADULTS?
J Ayub Med Coll Abbottabad. 2015 Apr-Jun;27(2):458-63.
3
Correction: Treatment with Vitamin D/MOG Association Suppresses Experimental Autoimmune Encephalomyelitis.
PLoS One. 2015 Jul 17;10(7):e0131260. doi: 10.1371/journal.pone.0131260. eCollection 2015.
4
Vitamin D for the prevention of cardiovascular disease: Are we ready for that?
Atherosclerosis. 2015 Aug;241(2):729-40. doi: 10.1016/j.atherosclerosis.2015.06.034. Epub 2015 Jun 21.
5
Vitamin D Antagonises the Suppressive Effect of Inflammatory Cytokines on CTLA-4 Expression and Regulatory Function.
PLoS One. 2015 Jul 2;10(7):e0131539. doi: 10.1371/journal.pone.0131539. eCollection 2015.
6
Deletion of macrophage Vitamin D receptor promotes insulin resistance and monocyte cholesterol transport to accelerate atherosclerosis in mice.
Cell Rep. 2015 Mar 24;10(11):1872-86. doi: 10.1016/j.celrep.2015.02.043.
7
[Current Topics on Vitamin D. Vitamin D and chronic kidney disease].
Clin Calcium. 2015 Mar;25(3):413-23.
8
Induced differentiation of human myeloid leukemia cells into M2 macrophages by combined treatment with retinoic acid and 1α,25-dihydroxyvitamin D3.
PLoS One. 2014 Nov 19;9(11):e113722. doi: 10.1371/journal.pone.0113722. eCollection 2014.
9
Vitamin D prevents endothelial damage induced by increased neutrophil extracellular traps formation in patients with systemic lupus erythematosus.
Acta Med Indones. 2014 Jul;46(3):189-98.
10
1,25-Dihydroxyvitamin D3 and its analog TX527 promote a stable regulatory T cell phenotype in T cells from type 1 diabetes patients.
PLoS One. 2014 Oct 3;9(10):e109194. doi: 10.1371/journal.pone.0109194. eCollection 2014.
Zotero 插件