Shiran M B, Barzegar Marvasti M, Shakeri-Zadeh A, Shahidi M, Tabkhi N, Farkhondeh F, Kalantar E, Asadinejad A
Department of Medical Physics, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran.
Department of Hematology, Faculty of Allied Medical Sciences, Iran University of Medical Sciences, Tehran, Iran.
J Biomed Phys Eng. 2017 Jun 1;7(2):107-116. eCollection 2017 Jun.
Hemodialysis is a process of removing waste and excess fluid from blood when kidneys cannot function efficiently. It often involves diverting blood to the filter of the dialysis machin to be cleared of toxic substances. Fouling of pores in dialysis membrane caused by adhesion of plasma protein and other toxins will reduce the efficacy of the filtre.
In This study, the influence of pulsed ultrasound waves on diffusion and the prevention of fouling in the filter membrane were investigated.
Pulsed ultrasound waves with frequency of 1 MHz at an intensity of 1 W/cm2 was applied to the high flux (PES 130) filter. Blood and blood equivalent solutions were passed through the filter in separate experimental setups. The amount of Creatinine, Urea and Inulin cleared from both blood equvalent solution and human whole blood passed through High Flux (PES 130) filter were measured in the presence and absence of ultrasound irradiation. Samples were taken from the outlet of the dialyzer every five minutes and the clearance of each constituent was calculated.
Statistical analysis of the blood equvalent solution and whole blood indicated the clearance of Urea and Inulin in the presence of ultrasound increased (p<0.05), while no significant effects were observed for Creatinine.
It may be concluded that ultrasound, as a mechanical force, can increase the rate of clearance of some toxins (such as middle and large molecules) in the hemodialysis process.
当肾脏无法有效发挥功能时，血液透析是一种从血液中清除废物和多余液体的过程。它通常涉及将血液转移到透析机的过滤器中以清除有毒物质。血浆蛋白和其他毒素的粘附导致透析膜孔隙堵塞会降低过滤器的功效。
在本研究中，研究了脉冲超声波对扩散的影响以及对滤膜污垢的预防作用。
将频率为1 MHz、强度为1 W/cm²的脉冲超声波施加于高通量（PES 130）过滤器。在单独的实验装置中，使血液和血液等效溶液通过过滤器。在有和没有超声照射的情况下，测量从通过高通量（PES 130）过滤器的血液等效溶液和人全血中清除的肌酐、尿素和菊粉的量。每五分钟从透析器出口取样，并计算每种成分的清除率。
对血液等效溶液和全血的统计分析表明，在有超声的情况下，尿素和菊粉的清除率增加（p<0.05），而肌酐未观察到显著影响。
可以得出结论，超声作为一种机械力，可以提高血液透析过程中某些毒素（如中大分子）的清除率。
