Moujaber Ossama, Omran Nawal, Kodiha Mohamed, Pié Brigitte, Cooper Ellis, Presley John F, Stochaj Ursula
Physiology, McGill University, Montreal, Canada.
Anatomy & Cell Biology, McGill University, Montreal, Canada.
Data Brief. 2017 May 19;13:115-123. doi: 10.1016/j.dib.2017.05.028. eCollection 2017 Aug.
SUN proteins participate in diverse cellular activities, many of which are connected to the nuclear envelope. Recently, the family member SUN1 has been linked to novel biological activities. These include the regulation of nucleoli, intranuclear compartments that assemble ribosomal subunits. We show that SUN1 associates with nucleoli in several mammalian epithelial cell lines. This nucleolar localization is not shared by all cell types, as SUN1 concentrates at the nuclear envelope in ganglionic neurons and non-neuronal satellite cells. Database analyses and Western blotting emphasize the complexity of SUN1 protein profiles in different mammalian cells. We constructed a STRING network which identifies SUN1-related proteins as part of a larger network that includes several nucleolar proteins. Taken together, the current data highlight the diversity of SUN1 proteins and emphasize the possible links between SUN1 and nucleoli.
SUN蛋白参与多种细胞活动，其中许多活动与核膜相关。最近，SUN家族成员SUN1已与新的生物学活性联系起来。这些活性包括对核仁的调控，核仁是组装核糖体亚基的核内区室。我们发现SUN1在几种哺乳动物上皮细胞系中与核仁相关联。并非所有细胞类型都有这种核仁定位，因为SUN1在神经节神经元和非神经元卫星细胞中集中于核膜。数据库分析和蛋白质免疫印迹强调了不同哺乳动物细胞中SUN1蛋白谱的复杂性。我们构建了一个STRING网络，该网络将SUN1相关蛋白识别为一个更大网络的一部分，该更大网络包括几种核仁蛋白。综上所述，当前数据突出了SUN1蛋白的多样性，并强调了SUN1与核仁之间可能存在的联系。
