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较低的基线生发中心活性和保留的Th1免疫与接受治疗的HIV感染患者的乙肝疫苗反应相关。

Lower Baseline Germinal Center Activity and Preserved Th1 Immunity Are Associated With Hepatitis B Vaccine Response in Treated HIV Infection.

作者信息

Paris Robert M, Milagres Lucimar G, Moysi Eirini, Okulicz Jason F, Agan Brian K, Ganesan Anu, Petrovas Constantinos, Koup Richard A

机构信息

US Military Malaria Research Program, Walter Reed Army Institute of Research, Silver Spring, Maryland.

Immunology Laboratory, Vaccine Research Center, NIAID, NIH, Bethesda, Maryland.

出版信息

Pathog Immun. 2017;2(1):66-88. doi: 10.20411/pai.v2i1.175. Epub 2017 Mar 14.

DOI:10.20411/pai.v2i1.175
PMID:28580437
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5450971/
Abstract

BACKGROUND

Why HIV-infected individuals have poor responses to standard dose and schedule hepatitis B virus immunization is not well understood.

METHODS

We compared the serologic and cellular immune profiles of treated HIV-infected individuals with similar durations of infection and preserved CD4 counts (> 350 cells/microliter) by hepatitis B vaccine (HBV) response before and after vaccination.

RESULTS

Similar levels of immune activation and plasma cytokine profile were found between non-responders and responders. The baseline plasma levels of CXCL-13, a surrogate of germinal center reactivity, were significantly lower in HBV responders compared to HBV non-responders and were a predictor of both vaccine response and titer. Furthermore, response to HBV vaccination was associated with a significantly higher frequency of circulating IgG memory B cells post vaccination and preserved Th1 antigen-specific T-cell responses.

CONCLUSIONS

Taken together, our data suggest that preserved Th1 responses are associated with hepatitis B vaccine response in treated HIV infection.

摘要

背景

目前尚不清楚为何感染HIV的个体对标准剂量和程序的乙型肝炎病毒免疫接种反应不佳。

方法

我们比较了感染持续时间相似且CD4细胞计数保持在>350个细胞/微升的接受治疗的HIV感染者在接种乙型肝炎疫苗（HBV）前后的血清学和细胞免疫特征。

结果

无应答者和应答者之间发现了相似水平的免疫激活和血浆细胞因子谱。生发中心反应性替代指标CXCL-13的基线血浆水平在HBV应答者中显著低于HBV无应答者，并且是疫苗反应和滴度的预测指标。此外，对HBV疫苗接种的反应与接种后循环IgG记忆B细胞的频率显著更高以及Th1抗原特异性T细胞反应的保持有关。

结论

综上所述，我们的数据表明，在接受治疗的HIV感染中，保持Th1反应与乙型肝炎疫苗反应相关。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e83e/6423955/0d2ffc6dc0df/pai-2-066-s005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e83e/6423955/f52b96624232/pai-2-066-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e83e/6423955/cccde6f71cf6/pai-2-066-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e83e/6423955/e78eea987e8e/pai-2-066-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e83e/6423955/8f6dafa00588/pai-2-066-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e83e/6423955/025c4fc23f9b/pai-2-066-s001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e83e/6423955/4fd80a27fc4f/pai-2-066-s002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e83e/6423955/79fc2e3b566c/pai-2-066-s003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e83e/6423955/0c720d603c6e/pai-2-066-s004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e83e/6423955/0d2ffc6dc0df/pai-2-066-s005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e83e/6423955/f52b96624232/pai-2-066-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e83e/6423955/cccde6f71cf6/pai-2-066-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e83e/6423955/e78eea987e8e/pai-2-066-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e83e/6423955/8f6dafa00588/pai-2-066-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e83e/6423955/025c4fc23f9b/pai-2-066-s001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e83e/6423955/4fd80a27fc4f/pai-2-066-s002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e83e/6423955/79fc2e3b566c/pai-2-066-s003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e83e/6423955/0c720d603c6e/pai-2-066-s004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e83e/6423955/0d2ffc6dc0df/pai-2-066-s005.jpg

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