Thacoor Amitabh
Department of Cardiac Surgery, Leeds General Infirmary, Great George Street, Leeds, United KIngdom.
Congenit Heart Dis. 2017 Jul;12(4):430-434. doi: 10.1111/chd.12467. Epub 2017 Jun 5.
Marfan syndrome is a multisystemic genetic condition affecting connective tissue. It carries a reduced life expectancy, largely dependent on cardiovascular complications. More common cardiac manifestations such as aortic dissection and aortic valve incompetence have been widely documented in the literature. Mitral valve prolapse (MVP), however, has remained poorly documented. This article aims at exploring the existing literature on the pathophysiology and diagnosis of MVP in patients with Marfan syndrome, defining its current management and outlining the future developments surrounding it.
马凡综合征是一种影响结缔组织的多系统遗传性疾病。它会缩短预期寿命，很大程度上取决于心血管并发症。文献中已广泛记载了更常见的心脏表现，如主动脉夹层和主动脉瓣关闭不全。然而，二尖瓣脱垂（MVP）的相关记载仍然很少。本文旨在探讨关于马凡综合征患者二尖瓣脱垂的病理生理学和诊断的现有文献，明确其当前的治疗方法，并概述围绕它的未来发展。
