Institute for Research in Biomedicine, Via Vincenzo Vela 6, CH-6500 Bellinzona, Switzerland.
Humanitas University, Department of Biomedical Sciences, Via Manzoni 113, 20089 Rozzano (Milan), Italy.
Nat Rev Immunol. 2017 Oct;17(10):595-607. doi: 10.1038/nri.2017.51. Epub 2017 Jun 5.
Early responses to invading pathogens and to non-microbial danger signals are mediated by different innate immune and parenchymal tissue cells, which are able to respond to a variety of pathogen- and danger-associated molecular patterns. In most if not all instances, innate immune responses to a given molecule are not uniquely confined to one responding cell type, but instead involve the engagement of different cells with intrinsically distinct properties. In this Review, we discuss the molecular basis of the differentiation of myeloid cells, which is controlled by transcription factors, transcriptional co-regulators and post-transcriptional mechanisms, and examine how the functional specification of the resulting mature immune cells of the myeloid lineage affects their response to danger signals.
早期对入侵病原体和非微生物危险信号的反应是由不同的先天免疫和实质组织细胞介导的，这些细胞能够对各种病原体和危险相关的分子模式作出反应。在大多数（如果不是全部的话）情况下，对特定分子的先天免疫反应并不局限于一种反应细胞类型，而是涉及具有内在不同特性的不同细胞的参与。在这篇综述中，我们讨论了转录因子、转录共调节剂和转录后机制控制的髓样细胞分化的分子基础，并研究了髓样谱系中成熟免疫细胞的功能特异性如何影响它们对危险信号的反应。
