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1型糖尿病幼儿使用胰岛素泵:社会人口学因素及家长报告的障碍

Insulin Pump Use in Young Children with Type 1 Diabetes: Sociodemographic Factors and Parent-Reported Barriers.

作者信息

Commissariat Persis V, Boyle Claire T, Miller Kellee M, Mantravadi Manasa G, DeSalvo Daniel J, Tamborlane William V, Van Name Michelle A, Anderson Barbara J, DiMeglio Linda A, Laffel Lori M

机构信息

1 Joslin Diabetes Center , Harvard Medical School, Boston, Massachusetts.

2 Jaeb Center for Health Research , Tampa, Florida.

出版信息

Diabetes Technol Ther. 2017 Jun;19(6):363-369. doi: 10.1089/dia.2016.0375. Epub 2017 Jun 5.

Abstract

BACKGROUND

Managing type 1 diabetes (T1D) in young children presents challenges to families and caregivers. Pump therapy may reduce challenges and benefit glycemic control. However, pump use is not universal; parent-reported reasons for lack of uptake are not well described.

METHODS

Parents of children <7, with T1D for ≥1 year, in the T1D Exchange registry completed surveys capturing demographic and clinical characteristics, as well as barriers to pump use. Data from pump users were compared to nonusers, and barriers were analyzed among parents who received pump recommendations, but decided against uptake.

RESULTS

Young children (N = 515) from 41 sites were identified (mean age 5.2 ± 1.2 years, diabetes duration 2.4 ± 1.0 years, 46% female, and 78% Non-Hispanic White). Overall glycemic control was suboptimal (HbA1c 8.1% ± 1.0%). The majority were pump users (64%, n = 331; nonusers 36%, n = 184). Pump users had longer T1D duration (2.5 ± 1.1 years vs. 2.2 ± 1.0 years, P = 0.001), were more likely to have annual household incomes ≥$75,000 (62% vs. 36%, P < 0.001), have a parent with college education or higher (70% vs. 45%, P < 0.001), perform more frequent blood glucose monitoring (7.5 ± 2.5 times/day vs. 6.5 ± 2.3 times/day, P < 0.001), and use continuous glucose monitoring (CGM) (45% vs. 13%, P < 0.001). Only income, education, frequency of blood glucose monitoring, and CGM use remained significant in a multivariate model including age, sex, ethnicity, and duration of diabetes. Barriers to pump uptake included concerns with physical interference, therapeutic effectiveness, and to a lesser extent, financial burden.

CONCLUSIONS

These findings provide an opportunity to address potentially modifiable parent-reported barriers to pump uptake through education and behavioral intervention.

摘要

背景

管理幼儿的1型糖尿病(T1D)给家庭和护理人员带来了挑战。胰岛素泵治疗可能会减少这些挑战并有利于血糖控制。然而,胰岛素泵的使用并不普遍;家长报告的未采用胰岛素泵的原因并未得到充分描述。

方法

T1D交流注册中心中患有T1D≥1年的7岁以下儿童的家长完成了调查,内容包括人口统计学和临床特征以及使用胰岛素泵的障碍。将胰岛素泵使用者的数据与非使用者的数据进行比较,并对那些收到胰岛素泵推荐但决定不采用的家长中的障碍因素进行分析。

结果

确定了来自41个地点的幼儿(N = 515)(平均年龄5.2±1.2岁,糖尿病病程2.4±1.0年,46%为女性,78%为非西班牙裔白人)。总体血糖控制不理想(糖化血红蛋白[HbA1c]为8.1%±1.0%)。大多数是胰岛素泵使用者(64%,n = 331;非使用者36%,n = 184)。胰岛素泵使用者的T1D病程更长(2.5±1.1年对2.2±1.0年,P = 0.001),更有可能家庭年收入≥75,000美元(62%对36%,P < 0.001),有一位受过大学教育或更高教育程度的家长(70%对45%,P < 0.001),更频繁地进行血糖监测(7.5±2.5次/天对6.5±2.3次/天,P < 0.001),并且使用持续葡萄糖监测(CGM)(45%对13%,P < 0.001)。在一个包括年龄、性别、种族和糖尿病病程的多变量模型中,只有收入、教育程度、血糖监测频率和CGM的使用仍然具有统计学意义。采用胰岛素泵的障碍包括对身体干扰、治疗效果的担忧,以及在较小程度上对经济负担的担忧。

结论

这些发现提供了一个机会,可通过教育和行为干预来解决家长报告的可能可改变的采用胰岛素泵的障碍。

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本文引用的文献

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The T1D Exchange clinic registry.
J Clin Endocrinol Metab. 2012 Dec;97(12):4383-9. doi: 10.1210/jc.2012-1561. Epub 2012 Sep 20.
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Effectiveness of sensor-augmented insulin-pump therapy in type 1 diabetes.
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