Kooiman Judith, Gurm Hitinder S
Department of Thrombosis and Hemostasis, Leiden University Medical Center, Leiden, South Holland, The Netherlands; Department of Nephrology, Leiden University Medical Center, Leiden, South Holland, The Netherlands.
Division of Cardiovascular Medicine, Department of Internal Medicine, Frankel Cardiovascular Center, University of Michigan Health System, University of Michigan Cardiovascular Center, 2A394, 1500 E. Medical Center Drive, Ann Arbor, MI 48109-5853, USA.
Interv Cardiol Clin. 2014 Jul;3(3):369-377. doi: 10.1016/j.iccl.2014.03.005. Epub 2014 Jun 28.
Risk scores should undergo 3 analytical phases before they are suitable for adoption in clinical practice, namely, derivation, external validation, and assessment of effect on clinical outcomes of use of the risk score in a so-called impact study. Major risk factors for renal complications after percutaneous coronary intervention are pre-existing chronic kidney disease, diabetes mellitus, use of a high contrast dose, and hemodynamic instability. Unfortunately, only 3 of these 10 risk scores have undergone external validation. As a result, there is a great need for further research on the already designed risk scores.
在风险评分适用于临床实践之前,应经历三个分析阶段,即推导、外部验证以及在所谓的影响研究中评估使用该风险评分对临床结局的影响。经皮冠状动脉介入治疗后发生肾脏并发症的主要危险因素包括已存在的慢性肾脏病、糖尿病、高造影剂剂量的使用以及血流动力学不稳定。遗憾的是,这10个风险评分中只有3个经过了外部验证。因此,对于已设计好的风险评分,非常有必要进行进一步研究。