金黄色葡萄球菌VraX通过与C1q结合特异性抑制补体经典途径。
Staphylococcus aureus VraX specifically inhibits the classical pathway of complement by binding to C1q.
作者信息
Yan Jun, Han Dianpeng, Liu Chenghua, Gao Yaping, Li Di, Liu Yu, Yang Guang
机构信息
Beijing Institute of Basic Medical Sciences, Beijing, China; State key Laboratory of Toxicology and Medical Countermeasures, Beijing, China.
Beijing Institute of Basic Medical Sciences, Beijing, China; State key Laboratory of Toxicology and Medical Countermeasures, Beijing, China.
出版信息
Mol Immunol. 2017 Aug;88:38-44. doi: 10.1016/j.molimm.2017.05.018. Epub 2017 Jun 2.
VraX is a protein secreted by Staphylococcus aureus, an important human pathogen. A dramatic over expression of VraX is observed when S. aureus is exposed to several antimicrobial agents; however, its function remains unclear. Here, we aimed to reveal the function of this protein and the mechanism by which it affects the immune system to enhance the pathogenesis of the bacterium. Our results showed that VraX specifically inhibited the classical pathway of the complement system. In particular, VraX could bind to the C1q protein and block the formation of the C1 complex. Deletion of VraX decreased the pathogenesis of S. aureus. Our findings indicate that over expression of VraX might be a protective response for S. aureus survival.
VraX是一种由金黄色葡萄球菌分泌的蛋白质，金黄色葡萄球菌是一种重要的人类病原体。当金黄色葡萄球菌暴露于几种抗菌剂时，可观察到VraX的显著过表达；然而，其功能仍不清楚。在此，我们旨在揭示该蛋白质的功能及其影响免疫系统以增强细菌致病性的机制。我们的结果表明，VraX特异性抑制补体系统的经典途径。特别是，VraX可与C1q蛋白结合并阻断C1复合物的形成。VraX的缺失降低了金黄色葡萄球菌的致病性。我们的研究结果表明，VraX的过表达可能是金黄色葡萄球菌生存的一种保护反应。
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