GRIK4基因常见变异与重度抑郁症：中国汉族人群的关联研究
Common variants in GRIK4 and major depressive disorder: An association study in the Chinese Han population.
作者信息
Ren Decheng, Bi Yan, Xu Fei, Niu Weibo, Zhang Rui, Hu Jiaxin, Guo Zhenming, Wu Xi, Cao Yanfei, Huang Xiaoye, Yang Fengping, Wang Lu, Li Weidong, Xu Yifeng, He Lin, Yu Tao, He Guang, Li Xingwang
机构信息
Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Shanghai Jiao Tong University, 1954 Huashan Road, Shanghai 200030, China; Shanghai Key Laboratory of Psychotic Disorders, Shanghai Institute of Mental Health, Shanghai Jiao Tong University, 600 South Wan Ping Road, Shanghai 200030, China.
Shanghai Key Laboratory of Psychotic Disorders, Shanghai Institute of Mental Health, Shanghai Jiao Tong University, 600 South Wan Ping Road, Shanghai 200030, China.
出版信息
Neurosci Lett. 2017 Jul 13;653:239-243. doi: 10.1016/j.neulet.2017.05.071. Epub 2017 Jun 2.
Major depressive disorder (MDD) is a common and complex mental disorder. Recent studies found that genetic variants located in GRIK4, which encoded glutamate ionotropic receptor kainate type subunit 4, was associated with the MDD. In this study, we intended to investigate whether GRIK4 gene was associated with MDD. So five single nucleotide polymorphisms (SNPs) were selected and genotyped (rs79526501, rs11218016, rs4582985, rs6589847, rs56275759) in 568 MDD patients and 846 healthy controls from Chinese Han population. The results showed that rs56275759 demonstrated statistically significant differences between MDD patients and control subjects both in allelic frequencies (p value=0.011) and genotypic frequencies (p value=0.029). Rs4582985 was excluded from the further analysis for its deviation from the Hardy-Weinberg equilibrium. Strong linkage disequilibrium (LD) was found among rs11218016, rs6589847 and rs56275759, and this block was significantly associated with MDD. In summary, our results firstly indicated that rs56275759 of GRIK4 gene might be associated with MDD in Chinese Han population.
重度抑郁症（MDD）是一种常见且复杂的精神障碍。最近的研究发现，位于GRIK4基因（该基因编码谷氨酸离子型红藻氨酸受体4亚基）中的基因变异与MDD有关。在本研究中，我们旨在调查GRIK4基因是否与MDD有关。因此，我们在中国汉族人群的568例MDD患者和846例健康对照中选择了5个单核苷酸多态性（SNP）进行基因分型（rs79526501、rs11218016、rs4582985、rs6589847、rs56275759）。结果显示，rs56275759在等位基因频率（p值 = 0.011）和基因型频率（p值 = 0.029）上，MDD患者与对照受试者之间均表现出统计学上的显著差异。由于rs4582985偏离哈迪 - 温伯格平衡，因此被排除在进一步分析之外。在rs11218016、rs6589847和rs56275759之间发现了强连锁不平衡（LD），并且该区域与MDD显著相关。总之，我们的结果首次表明，中国汉族人群中GRIK4基因的rs56275759可能与MDD有关。
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