Pu M, Wang X, Zhang J
Wuxi People's Hospital, No. 299 Qingyang road, 214000 Wuxi, China.
Wuxi People's Hospital, No. 299 Qingyang road, 214000 Wuxi, China.
Rev Neurol (Paris). 2020 Dec;176(10):823-828. doi: 10.1016/j.neurol.2019.11.009. Epub 2020 Mar 31.
An increasing body of research has focused on the functions of the glutamate receptor ionotropic kainate 4 (GRIK4) gene in treatment for depression, memory, as well as neurodegenerative diseases. It is widely recognized that major depressive disorder (MDD) patients often display cognitive dysfunctions, which do not strictly correlate with the severity of depressive symptoms, and in some individuals persist after clinical remission. However, little is known regarding the particular role of GRIK4 in cognitive functions of patients suffering from a MDD. The current study therefore sought to examine the impact of GRIK4 polymorphism on cognitive functions in MDD patients. A total of 217 MDD patients participated in this study. Their depressive severity was determined with the 17-item Hamilton Depression Rating Scale, and cognitive functions were evaluated using the Stroop Neuropsychological Screening Test, tests of visual reproduction and immediate logical memory, and the verbal fluency test (VFT). All patients were genotyped to determine GRIK4 polymorphisms. Results of VFT revealed statistical differences among all single-nucleotide polymorphism (SNP) genotypes. In the Stroop-color-word test, only rs6589847 was discovered to be statistically different. No significant difference was found in the Stroop-color task scores, the visual reproduction test, or the immediate logical memory test. GRIK4 polymorphism exerted a significant effect on long-term memory retrieval and selective attention, but did not affect immediate memory.
越来越多的研究聚焦于离子型红藻氨酸盐4（GRIK4）基因在抑郁症治疗、记忆以及神经退行性疾病方面的功能。人们普遍认识到，重度抑郁症（MDD）患者常常表现出认知功能障碍，这种障碍与抑郁症状的严重程度并非严格相关，并且在一些个体中，即使临床症状缓解后仍会持续存在。然而，关于GRIK4在MDD患者认知功能中的具体作用，人们所知甚少。因此，本研究旨在探讨GRIK4基因多态性对MDD患者认知功能的影响。共有217名MDD患者参与了本研究。使用17项汉密尔顿抑郁量表确定他们的抑郁严重程度，并通过Stroop神经心理学筛查测试、视觉再现测试、即刻逻辑记忆测试以及言语流畅性测试（VFT）评估认知功能。对所有患者进行基因分型以确定GRIK4基因多态性。VFT结果显示所有单核苷酸多态性（SNP）基因型之间存在统计学差异。在Stroop颜色-文字测试中，仅发现rs6589847存在统计学差异。在Stroop颜色任务得分、视觉再现测试或即刻逻辑记忆测试中未发现显著差异。GRIK4基因多态性对长期记忆提取和选择性注意力有显著影响，但不影响即刻记忆。
