Center for Regenerative Medicine, Yamaguchi University School of Medicine, Minami Kogushi 1-1-1, Ube Yamaguchi, 755-8505, Japan.
Department of Gastroenterology and Hepatology, Yamaguchi University Graduate School of Medicine, Minami Kogushi 1-1-1, Ube Yamaguchi, 755-8505, Japan.
Sci Rep. 2017 Jun 5;7(1):2749. doi: 10.1038/s41598-017-02924-5.
Lifestyle-related diseases have become a major issue in recent years. The increasing incidence of fatty liver underlines the urgency with which the issues of non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH) need to be addressed. L-carnitine is a compound known to transport fatty acids into the mitochondria to enhance β-oxidation-mediated metabolism of fats. In this study, the effects of L-carnitine administration on fatty liver of medaka (Oryzias latipes) were analysed, to check for disease improvement and metabolic changes. Additionally, the effects of the concomitant administration of L-carnitine and eicosapentaenoic acid (20:5n-3) (EPA) were investigated. Findings indicated reduced lipid deposition, increase in metabolites associated with β-oxidation, and significant reduction in fatty acid levels in the liver, implying improvement in fatty liver condition. Concomitant administration of L-carnitine and EPA resulted in further benefits, via changes in fatty acid composition in the medaka fatty liver model.
近年来，与生活方式相关的疾病已成为一个主要问题。脂肪肝发病率的不断上升，凸显了非酒精性脂肪肝（NAFLD）和非酒精性脂肪性肝炎（NASH）问题亟待解决的紧迫性。左旋肉碱是一种已知的能将脂肪酸转运到线粒体中，增强β-氧化介导的脂肪代谢的化合物。在这项研究中，分析了左旋肉碱给药对斑马鱼（Oryzias latipes）脂肪肝的影响，以检查疾病的改善和代谢变化。此外，还研究了左旋肉碱和二十碳五烯酸（20:5n-3）（EPA）同时给药的效果。研究结果表明，脂肪沉积减少，与β-氧化相关的代谢物增加，肝脏中的脂肪酸水平显著降低，表明脂肪肝状况得到改善。在斑马鱼脂肪肝模型中，通过改变脂肪酸组成，同时给予左旋肉碱和 EPA 可带来进一步的益处。
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