独特型抗真菌疫苗接种：抗独特型抗生素抗体介导的免疫保护作用

Idiotypic Antifungal Vaccination: Immunoprotection by Antiidiotypic Antibiotic Antibodies.

作者信息

Polonelli Luciano, Magliani Walter, Conti Stefania

机构信息

Unit of Biomedical, Biotechnological and Translational Sciences (S.Bi.Bi.T.), Department of Medicine and Surgery, University of Parma, Via Volturno 39, 43125, Parma, Italy.

出版信息

Methods Mol Biol. 2017;1625:97-112. doi: 10.1007/978-1-4939-7104-6_8.

DOI:10.1007/978-1-4939-7104-6_8

PMID:28584986

Abstract

As implied by the idiotypic network theory, the interaction between the functional epitope of a microbicidal molecule (X) and its specific cell-wall receptor (RX) on sensitive microorganisms may be imaged by the bond between the idiotype (Id) of a neutralizing monoclonal antibody (anti-X Ab) and its anti-idiotype (anti-Id) X-like Ab (anti-anti-X Ab). Consequently, anti-X Ab Id may mimic RX acting as a vaccine (idiotypic vaccination) for the elicitation of protective anti-Id Abs with antibiotic activity (antibiobodies).

摘要

正如独特型网络理论所暗示的那样，杀菌分子（X）的功能性表位与其在敏感微生物上的特异性细胞壁受体（RX）之间的相互作用，可以通过中和单克隆抗体（抗X抗体）的独特型（Id）与其抗独特型（抗Id）X样抗体（抗抗X抗体）之间的结合来模拟。因此，抗X抗体Id可以模拟RX，作为一种疫苗（独特型疫苗接种），用于引发具有抗生素活性的保护性抗Id抗体（抗生物质抗体）。