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一项基于人群的瑞典人对使用扑热息痛风险认知的研究——特别关注年轻人。

A population-based study of risk perceptions of paracetamol use among Swedes-with a special focus on young adults.

作者信息

Håkonsen H, Hedenrud T

机构信息

Department of Public Health and Community Medicine, Institute of Medicine, University of Gothenburg, Gothenburg, Sweden.

出版信息

Pharmacoepidemiol Drug Saf. 2017 Aug;26(8):992-997. doi: 10.1002/pds.4238. Epub 2017 Jun 5.

Abstract

PURPOSE

The purpose of this study was to investigate risk perceptions of paracetamol use, with a special focus on young adults.

METHODS

A web survey was sent to a representative sample (n = 5838) of the Swedish adult population. Altogether, 3120 persons answered the full questionnaire. Risk perceptions of paracetamol use in relation to sex, age, and education were determined using logistic regression.

RESULTS

Most respondents (70.5%) reported use of paracetamol in the 3 months prior to the study; the highest proportion was found among those aged 18 to 25 years (75.8%). Nine in 10 were over-the-counter (OTC) paracetamol users. A total of 14.2% thought paracetamol is completely harmless to use while 54.3% indicated risks associated with use even when following the dosing instructions. One third disagreed that it is less risky to use paracetamol compared with nonsteroidal antiinflammatory drugs. Three-quarters identified liver damage as a potential consequence of exceeding the recommended maximum daily dose. The likelihood of a high-risk perception was higher in women compared with men, and increased with age. No association was found between risk perception and educational status. Participants aged 18 to 25 years had the same ability to identify risks of overdose as did those aged 26 to 65, but expressed more careless attitudes towards use.

CONCLUSIONS

Although the study population purchased paracetamol primarily OTC, they demonstrated basic awareness of paracetamol use including the potential consequences of overdosing. Young adults (18-25 y), who were the most frequent users of OTC paracetamol, perceived less risk associated with use compared with older participants.

摘要

目的

本研究旨在调查对扑热息痛使用的风险认知,特别关注年轻成年人。

方法

向瑞典成年人口的代表性样本(n = 5838)发送了网络调查问卷。共有3120人回答了完整问卷。使用逻辑回归确定扑热息痛使用的风险认知与性别、年龄和教育程度的关系。

结果

大多数受访者(70.5%)报告在研究前3个月使用过扑热息痛;18至25岁人群中的比例最高(75.8%)。十分之九的人是扑热息痛非处方药使用者。共有14.2%的人认为使用扑热息痛完全无害,而54.3%的人表示即使遵循给药说明使用也存在风险。三分之一的人不同意与非甾体抗炎药相比,使用扑热息痛风险更低。四分之三的人认为超过推荐的最大日剂量可能导致肝损伤。女性对高风险的认知可能性高于男性,且随年龄增加。未发现风险认知与教育程度之间存在关联。18至25岁的参与者识别过量用药风险的能力与26至65岁的参与者相同,但对使用表现出更粗心的态度。

结论

尽管研究人群主要通过非处方药购买扑热息痛,但他们对扑热息痛的使用表现出基本的认知,包括过量用药的潜在后果。年轻成年人(18 - 25岁)是扑热息痛非处方药的最频繁使用者,与年龄较大的参与者相比,他们认为使用相关风险较低。

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