Morimoto K, Morisaka K, Kamada A
J Pharm Pharmacol. 1985 Feb;37(2):134-6. doi: 10.1111/j.2042-7158.1985.tb05024.x.
The effects of polyacrylic acid gel on the nasal absorption of insulin and [Asu1,7]-eel calcitonin were investigated in rats. The nasal administration of insulin (1 IU kg-1) in polyacrylic acid gel at 0.1 and 1% w/v showed maximum hypoglycaemic effects at 30 min and 1 h after administration, respectively. However, the nasal administration of insulin in carboxymethyl cellulose (1% w/v) solution had no hypoglycaemic effect at the same dose. When [Asu1,7]-eel calcitonin (10 U kg-1) was administered nasally in polyacrylic acid gel (0.1% w/v), a prominent hypocalcaemic effect was observed during the first 30 min. Nasal administration of [Asu1,7]-eel calcitonin in saline had no hypocalcaemic effect at the same dose. The results indicate that the polyacrylic acid gel base significantly enhanced the absorption of insulin and [Asu1,7]-eel calcitonin via the nasal cavity.
在大鼠中研究了聚丙烯酸凝胶对胰岛素和[Asu1,7]-鳗鱼降钙素经鼻腔吸收的影响。以0.1%和1%w/v的聚丙烯酸凝胶经鼻腔给予胰岛素（1IU/kg-1），分别在给药后30分钟和1小时显示出最大降血糖作用。然而，以相同剂量经鼻腔给予羧甲基纤维素（1%w/v）溶液中的胰岛素则没有降血糖作用。当以0.1%w/v的聚丙烯酸凝胶经鼻腔给予[Asu1,7]-鳗鱼降钙素（10U/kg-1）时，在最初30分钟内观察到显著的降钙作用。以相同剂量经鼻腔给予生理盐水中的[Asu1,7]-鳗鱼降钙素则没有降钙作用。结果表明，聚丙烯酸凝胶基质显著增强了胰岛素和[Asu1,7]-鳗鱼降钙素经鼻腔的吸收。
