Department of Urology, University of Illinois at Chicago, Chicago, IL, USA.
University of Southern California, Los Angeles, CA, USA.
Prostate Cancer Prostatic Dis. 2017 Dec;20(4):413-417. doi: 10.1038/pcan.2017.30. Epub 2017 Jun 6.
To evaluate whether the presence of both prostate atrophy (PA) and chronic prostate inflammation (CPI) in the same biopsy and in the same biopsy core are associated with prostate cancer (PCa) risk and grade in repeat biopsies.
Retrospective analyses of 6132 men who were 50-75 years old undergoing 2-year repeat prostate biopsy after a negative baseline biopsy for PCa in the REduction by DUtasteride of prostate Cancer Events (REDUCE) study. PA, CPI and PCa were determined by central pathology. The association of baseline PA and CPI with 2-year repeat biopsy cancer status and grade was evaluated with χ test and logistic regression controlling clinicopathological features.
PA, CPI and both were detected in 583 (9.5%), 1063 (17.4%) and 3675 (59.9%) baseline biopsies, respectively. Compared with biopsies with neither PA nor CPI, the presence of PA (odds ratio (OR)=0.73, 95% confidence interval (CI)=0.57-0.93), CPI (OR=0.72, 95% CI=0.58-0.88) and both (OR=0.54, 95% CI=0.45-0.64) were associated with lower PCa risk in the 2-year repeat prostate biopsy. Results were similar in multivariable analysis. Among subjects with both PA and CPI, those with both findings in the same core had even lower PCa risk compared with PA and CPI in different cores (univariable OR=0.68, 95% CI=0.51-0.91; multivariable OR=0.73, 95% CI=0.54-0.99). Combination of PA and CPI was associated with lower risk of high-grade PCa.
The presence of both PA and CPI in baseline biopsies, especially in the same core, was associated with lower PCa risk and grade. The presence and topographical distribution of PA and CPI may be used in PCa risk stratification.
评估同一活检和同一活检核心中前列腺萎缩（PA）和慢性前列腺炎（CPI）的共存是否与前列腺癌（PCa）风险和分级相关。
回顾性分析了 6132 名 50-75 岁男性，这些男性在 REDUCE 研究中基线前列腺活检阴性后进行了为期 2 年的重复前列腺活检。PA、CPI 和 PCa 由中心病理学确定。使用卡方检验和逻辑回归控制临床病理特征，评估基线 PA 和 CPI 与 2 年重复活检癌症状态和分级的相关性。
583（9.5%）、1063（17.4%）和 3675（59.9%）基线活检中分别检测到 PA、CPI 和两者。与既无 PA 也无 CPI 的活检相比，PA 存在（比值比（OR）=0.73，95%置信区间（CI）=0.57-0.93）、CPI（OR）=0.72，95%CI=0.58-0.88）和两者（OR=0.54，95%CI=0.45-0.64）与 2 年内重复前列腺活检中较低的 PCa 风险相关。多变量分析结果相似。在同时具有 PA 和 CPI 的患者中，与在不同核心中具有 PA 和 CPI 的患者相比，在同一核心中同时具有这两种发现的患者的 PCa 风险甚至更低（单变量 OR=0.68，95%CI=0.51-0.91；多变量 OR=0.73，95%CI=0.54-0.99）。PA 和 CPI 的组合与低级别 PCa 风险相关。
基线活检中同时存在 PA 和 CPI，特别是在同一核心中，与较低的 PCa 风险和分级相关。PA 和 CPI 的存在和分布可能用于 PCa 风险分层。
Zotero 插件