维拉帕米和地尔硫䓬对大鼠离体胃食管括约肌的作用。
Effect of verapamil and diltiazem on isolated gastro-oesophageal sphincter of the rat.
作者信息
Morales-Olivas F J, Cortijo J, Esplugues J V, Rubio E, Esplugues J
出版信息
J Pharm Pharmacol. 1985 Mar;37(3):208-9. doi: 10.1111/j.2042-7158.1985.tb05044.x.
Abstract
The effect of verapamil and diltiazem on the contraction induced by agonists on the rat lower oesophageal sphincter in-vitro has been studied. Both calcium entry blockers inhibited the contractile response to acetylcholine, carbachol and KCl. The potency of the inhibitory action was diltiazem greater than verapamil. The results give substance to the use of calcium entry blockers in the treatment of oesophageal spasm.
摘要
研究了维拉帕米和地尔硫䓬对大鼠离体下食管括约肌激动剂诱导收缩的影响。两种钙通道阻滞剂均抑制了对乙酰胆碱、卡巴胆碱和氯化钾的收缩反应。抑制作用的效力是地尔硫䓬大于维拉帕米。这些结果为钙通道阻滞剂用于治疗食管痉挛提供了依据。
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