Nasipuri R N, Omotosho J A
J Pharm Pharmacol. 1985 Mar;37(3):212-3. doi: 10.1111/j.2042-7158.1985.tb05046.x.
The effects of treating cassava starch with sodium lauryl sulphate and Polysorbate 80 and the method of incorporating the treated and plain starch as disintegrant on the physical properties of sulphadiazine tablets were investigated. Disintegration and dissolution rates were faster with starch in which surfactant was incorporated in dry state than with starch treated with solution of surfactant. A direct correlation was observed between the Hardness-Friability Index and T90 values. Polysorbate 80-treated starch exhibited a better dissolution profile than SLS-treated starch.
研究了用十二烷基硫酸钠和聚山梨酯80处理木薯淀粉的效果，以及将处理过的淀粉和普通淀粉作为崩解剂加入对磺胺嘧啶片物理性质的影响。与用表面活性剂溶液处理的淀粉相比，干态加入表面活性剂的淀粉的崩解和溶解速率更快。硬度-脆碎度指数与T90值之间存在直接相关性。聚山梨酯80处理的淀粉比十二烷基硫酸钠处理的淀粉表现出更好的溶出曲线。
