Shahzad Fazeela, Umar Naima
Department of Gynaecology and Obstetrics, Gujranwala Medical College/DHQ-Teaching Hospital, Gujranwala, Pakistan.
J Ayub Med Coll Abbottabad. 2016 Oct-Dec;28(4):698-701.
Prematurity is still a major problem for health care services throughout the world. Before the late 1980s, respiratory distress syndrome (RDS) was the primary cause of morbidity and mortality in preterm new-borns. Frequency of RDS and ensuing mortality in infants treated with antenatal steroid is less than those delivered without this therapy. Many pregnant females deliver before term or 37 weeks, hence may be advised this prophylactic therapy without creating significant maternal or foetal side effects.
It was a descriptive case-series conducted in the department of obstetrics and gynaecology, unit II of Jinnah Hospital Lahore for a period of 6 months.
The study sample of 230 was divided into two groups on the basis of exposure to dexamethasone. RDS was reported 76 (33.0%) cases (preterm neonates) in the study, out of these 26 (22.4%) cases belonged to exposed group and 50 (43.9%) cases belonged to non-exposed group. Mortality due to RDS among all preterm neonates with RDS occurred in total 29 (12.6%) preterm neonates in the study, out of these 5 (4.3%) cases belonged to exposed group and 24 (21.1%) belonged to non-exposed group.
Frequency of RDS and mortality due to this disease in group of infants treated with antenatal steroid is far less than the group of preterm new-borns delivered without this therapy.
早产仍是全球医疗服务面临的一个主要问题。在20世纪80年代末之前，呼吸窘迫综合征（RDS）是早产新生儿发病和死亡的主要原因。接受产前类固醇治疗的婴儿患RDS的频率及随之而来的死亡率低于未接受该治疗的婴儿。许多孕妇在足月前或37周前分娩，因此可建议她们接受这种预防性治疗，且不会产生明显的母体或胎儿副作用。
这是在拉合尔真纳医院第二产科和妇科进行的一项为期6个月的描述性病例系列研究。
根据是否接触地塞米松，将230名研究样本分为两组。该研究中报告了76例（33.0%）（早产新生儿）RDS病例，其中26例（22.4%）属于接触组，50例（43.9%）属于非接触组。该研究中，所有患有RDS的早产新生儿中，因RDS导致的死亡共有29例（12.6%）早产新生儿，其中5例（4.3%）属于接触组，24例（21.1%）属于非接触组。
接受产前类固醇治疗的婴儿组中RDS的发病率及因该病导致的死亡率远低于未接受该治疗的早产新生儿组。
