Geerling Gerd, Hille Konrad
Augenklinik, Universitätsklinikum Düsseldorf.
Augenklinik, Klinikum Offenburg.
Klin Monbl Augenheilkd. 2017 Jun;234(6):763-769. doi: 10.1055/s-0043-111086. Epub 2017 Jun 6.
In severe ocular surface disease with limbal stem cell deficiency associated with severe dry eye, penetrating keratoplasty is likely to fail. In these cases, and provided the posterior segment is normal, keratoprosthesis surgery (KPro) can achieve visual rehabilitation. In KPros with an autologous biological haptic, a bone-tooth-complex (osteo-odonto-keratoprothesis, OOKPro) or a piece of tibial cortex (tibia-keratoprosthesis, TKPro) is used to carry a PMMA cylinder. This construct can successfully be implanted even in severely dry eyes and in those with autoimmune disease, in which other KPro designs frequently fail. Herein we review the published anatomic long-term results of OOKPro and TKPro on our own patients. With a mean follow-up of 7.5 years (max. 20.6) for OOKPro and 4.5 years (max. 13.3) for TKPro patients, the retention rate was 91 and 86%, respectively. We are unaware of any other technique for artificial replacement of the cornea with equally positive long-term results as KPros with a biological haptic.
在伴有严重干眼的角膜缘干细胞缺乏的严重眼表疾病中，穿透性角膜移植术很可能失败。在这些情况下，并且如果眼后段正常，角膜假体手术（KPro）可以实现视力康复。在带有自体生物触觉装置的角膜假体中，骨 - 牙复合物（骨 - 牙 - 角膜假体，OOKPro）或一片胫骨皮质（胫骨 - 角膜假体，TKPro）用于支撑一个聚甲基丙烯酸甲酯圆柱体。即使在严重干眼和自身免疫性疾病患者中，这种结构也能成功植入，而其他角膜假体设计在这些患者中常常失败。在此我们回顾已发表的关于我们自己患者的OOKPro和TKPro的解剖学长期结果。OOKPro患者平均随访7.5年（最长20.6年），TKPro患者平均随访4.5年（最长13.3年），保留率分别为91%和86%。我们不知道有任何其他人工角膜置换技术能像带有生物触觉装置的角膜假体一样取得同样积极的长期效果。
