Gao Na, Chen Yong-Xiang, Zhao Yu-Fen, Li Yan-Mei
Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology (Ministry of Education), Department of Chemistry, Tsinghua University, Beijing 100084, China.
Beijing Institute for Brain Disorders, Beijing 100069, China.
Molecules. 2017 Jun 1;22(6):916. doi: 10.3390/molecules22060916.
Amyloid proteins are closely related with amyloid diseases and do tremendous harm to human health. However, there is still a lack of effective strategies to treat these amyloid diseases, so it is important to develop novel methods. Accelerating the clearance of amyloid proteins is a favorable method for amyloid disease treatment. Recently, chemical methods for protein reduction have been developed and have attracted much attention. In this review, we focus on the latest progress of chemical methods that knock down amyloid proteins, including the proteolysis-targeting chimera (PROTAC) strategy, the "recognition-cleavage" strategy, the chaperone-mediated autophagy (CMA) strategy, the selectively light-activatable organic and inorganic molecules strategy and other chemical strategies.
淀粉样蛋白与淀粉样疾病密切相关，对人类健康造成极大危害。然而，目前仍缺乏治疗这些淀粉样疾病的有效策略，因此开发新方法至关重要。加速淀粉样蛋白的清除是治疗淀粉样疾病的一种有利方法。近年来，已开发出用于蛋白质降解的化学方法，并引起了广泛关注。在本综述中，我们重点关注降解淀粉样蛋白的化学方法的最新进展，包括蛋白酶靶向嵌合体（PROTAC）策略、“识别-切割”策略、伴侣介导的自噬（CMA）策略、选择性光激活有机和无机分子策略以及其他化学策略。
