School of Instrument Science and Engineering, Southeast University, Nanjing 210096, China.
Sensors (Basel). 2017 Jun 1;17(6):1256. doi: 10.3390/s17061256.
The imbalance between limited organ supply and huge potential need has hindered the development of organ-graft techniques. In this paper a low-cost hypothermic machine perfusion (HMP) device is designed and implemented to maintain suitable preservation surroundings and extend the survival life of isolated organs. Four necessary elements (the machine perfusion, the physiological parameter monitoring, the thermostatic control and the oxygenation apparatus) involved in this HMP device are introduced. Especially during the thermostatic control process, a modified Bayes estimation, which introduces the concept of improvement factor, is realized to recognize and reduce the possible measurement errors resulting from sensor faults and noise interference. Also, a fuzzy-PID controller contributes to improve the accuracy and reduces the computational load using the DSP. Our experiments indicate that the reliability of the instrument meets the design requirements, thus being appealing for potential clinical preservation applications.
器官供体的严重短缺与巨大的潜在需求之间的不平衡严重阻碍了器官移植技术的发展。本文设计并实现了一种低成本的低温机器灌注（HMP）设备，以维持合适的保存环境并延长离体器官的存活时间。本文介绍了该 HMP 设备中涉及的四个必要元素（机器灌注、生理参数监测、恒温控制和供氧设备）。特别是在恒温控制过程中，实现了一种改进的贝叶斯估计，该估计引入了改进因子的概念，以识别和减少可能由传感器故障和噪声干扰引起的测量误差。此外，模糊 PID 控制器使用 DSP 提高了精度并降低了计算量。我们的实验表明，该仪器的可靠性满足设计要求，因此非常适合潜在的临床保存应用。
