CD27 marks murine embryonic hematopoietic stem cells and type II prehematopoietic stem cells.
作者信息
Li Yan, Gao Long, Hadland Brandon, Tan Kai, Speck Nancy A
机构信息
Abramson Family Cancer Research Institute and.
Department of Cell and Developmental Biology, University of Pennsylvania, Philadelphia PA.
出版信息
Blood. 2017 Jul 20;130(3):372-376. doi: 10.1182/blood-2017-03-776849. Epub 2017 Jun 6.
Abstract
摘要
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CD70/CD27 signaling promotes blast stemness and is a viable therapeutic target in acute myeloid leukemia.CD70/CD27信号传导促进原始细胞干性，是急性髓系白血病中一个可行的治疗靶点。
J Exp Med. 2017 Feb;214(2):359-380. doi: 10.1084/jem.20152008. Epub 2016 Dec 28.
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Tracing haematopoietic stem cell formation at single-cell resolution.单细胞分辨率追踪造血干细胞的形成。
Nature. 2016 May 26;533(7604):487-92. doi: 10.1038/nature17997. Epub 2016 May 18.
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Concealed expansion of immature precursors underpins acute burst of adult HSC activity in foetal liver.未成熟前体细胞的隐匿性扩增是胎儿肝脏中成年造血干细胞活性急性爆发的基础。
Development. 2016 Apr 15;143(8):1284-9. doi: 10.1242/dev.131193.
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CD201 and CD27 identify hematopoietic stem and progenitor cells across multiple murine strains independently of Kit and Sca-1.CD201和CD27可独立于Kit和Sca-1鉴定多种小鼠品系中的造血干细胞和祖细胞。
Exp Hematol. 2015 Jul;43(7):578-85. doi: 10.1016/j.exphem.2015.04.001. Epub 2015 Apr 16.
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Endothelium and NOTCH specify and amplify aorta-gonad-mesonephros-derived hematopoietic stem cells.内皮细胞和NOTCH信号决定并扩增源自主动脉-性腺-中肾的造血干细胞。
J Clin Invest. 2015 May;125(5):2032-45. doi: 10.1172/JCI80137. Epub 2015 Apr 13.
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Whole-transcriptome analysis of endothelial to hematopoietic stem cell transition reveals a requirement for Gpr56 in HSC generation.内皮细胞向造血干细胞转变的全转录组分析揭示了造血干细胞生成过程中对Gpr56的需求。
J Exp Med. 2015 Jan 12;212(1):93-106. doi: 10.1084/jem.20140767. Epub 2014 Dec 29.
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Tracing the origin of the HSC hierarchy reveals an SCF-dependent, IL-3-independent CD43(-) embryonic precursor.追踪 HSC 层级的起源揭示了一个依赖于 SCF、不依赖于 IL-3 的 CD43(-) 胚胎前体。
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Stem Cells Dev. 2014 Jun 1;23(11):1168-77. doi: 10.1089/scd.2013.0536. Epub 2014 Feb 18.
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