Perçin Gülce, Riege Konstantin, Fröbel Julia, Metz Jonas, Culemann Stephan, Lesche Mathias, Reinhardt Susanne, Höfer Thomas, Hoffmann Steve, Waskow Claudia
Immunology of Aging, Leibniz Institute on Aging - Fritz Lipmann Institute (FLI), Jena, Germany.
Computational Biology of Aging, Leibniz Institute on Aging - Fritz Lipmann Institute (FLI), Jena, Germany.
Nat Commun. 2025 May 14;16(1):4428. doi: 10.1038/s41467-025-59059-9.
Embryonic macrophages emerge before the onset of definitive hematopoiesis, seed into discrete tissues and contribute to specialized resident macrophages throughout life. Presence of embryonic macrophages in the bone marrow and functional impact on hematopoietic stem cells (HSC) or the niche remains unclear. Here we show that bone marrow macrophages consist of two ontogenetically distinct cell populations from embryonic and adult origin. Newborn mice lacking embryonic macrophages have decreased HSC numbers in the bone marrow suggesting an important function for embryo-derived macrophages in orchestrating HSC trafficking around birth. The establishment of a normal cellular niche space in the bone marrow critically depends on embryonic macrophages that are important for the development of mesenchymal stromal cells, but not other non-hematopoietic niche cells, providing evidence for a specific role for embryo-derived macrophages in the establishment of the niche environment pivotal for the establishment of a normally sized HSC pool.
胚胎巨噬细胞在确定性造血开始之前出现，定植于离散组织，并在整个生命过程中对特化的驻留巨噬细胞产生影响。骨髓中胚胎巨噬细胞的存在及其对造血干细胞（HSC）或造血微环境的功能影响仍不清楚。在这里，我们表明骨髓巨噬细胞由来自胚胎和成年来源的两个在个体发生上不同的细胞群体组成。缺乏胚胎巨噬细胞的新生小鼠骨髓中的造血干细胞数量减少，这表明胚胎来源的巨噬细胞在出生前后协调造血干细胞运输方面具有重要功能。骨髓中正常细胞微环境空间的建立关键取决于胚胎巨噬细胞，胚胎巨噬细胞对间充质基质细胞的发育很重要，但对其他非造血微环境细胞不重要，这为胚胎来源的巨噬细胞在建立对正常大小造血干细胞池的建立至关重要的微环境环境中发挥特定作用提供了证据。
