H1受体阻滞剂单独及与吗啡联合应用对小鼠产生抗伤害感受的作用。
Effect of H1 blockers alone and in combination with morphine to produce antinociception in mice.
作者信息
Sun C L, Hui F W, Hanig J P
出版信息
Neuropharmacology. 1985 Jan;24(1):1-4. doi: 10.1016/0028-3908(85)90086-3.
PMID:2858829
Abstract
Antinociception was assessed in male CD-1 mice by a modification of Haffner's tail-clamp procedure. The H1 blockers, including an ethylenediamine (pyrilamine), an ethanolamine (diphenhydramine), a phenothiazine (methdilazine), a piperazine (cyclizine) and an alkylamine (chlorpheniramine), all produced antinociception when given alone to mice and also caused potentiation when combined with morphine.
摘要
通过对哈夫纳尾夹法进行改进，在雄性CD-1小鼠中评估镇痛作用。H1受体阻滞剂，包括一种乙二胺类（吡苄明）、一种乙醇胺类（苯海拉明）、一种吩噻嗪类（甲哌氯丙嗪）、一种哌嗪类（赛克利嗪）和一种烷基胺类（氯苯那敏），单独给予小鼠时均产生镇痛作用，与吗啡合用时也会产生增效作用。
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