抗精神病药物对脑β-内啡肽免疫反应性的影响。

Effects of neuroleptic drugs on brain beta-endorphin immunoreactivity.

作者信息

Beal M F, Fisher J, Carr D B, Martin J B

出版信息

Neurosci Lett. 1985 Jan 21;53(2):173-8. doi: 10.1016/0304-3940(85)90181-8.

Abstract

The effect of chronic haloperidol on brain beta-endorphin immunoreactivity was examined in rats. Chronic haloperidol resulted in significant reductions of beta-endorphin immunoreactivity within the striatum, but other brain regions were uneffected. When a variety of neuroleptic drugs were tested, fluphenazine, chlorpromazine and haloperidol resulted in comparable reductions in beta-endorphin immunoreactivity in the striatum. These findings suggest a functional interaction between beta-endorphin and dopamine systems in the striatum.

摘要

研究了慢性给予氟哌啶醇对大鼠脑内β-内啡肽免疫反应性的影响。慢性给予氟哌啶醇导致纹状体内β-内啡肽免疫反应性显著降低，但其他脑区未受影响。当测试多种抗精神病药物时，氟奋乃静、氯丙嗪和氟哌啶醇导致纹状体内β-内啡肽免疫反应性出现类似程度的降低。这些发现提示纹状体内β-内啡肽与多巴胺系统之间存在功能相互作用。