Liu Na, Meng Zhaowei, Jia Qiang, He Xianghui, Tian Weijun, Tan Jian, Zhang Yujie, Li Xue, Hu Tianpeng, Zhou Pingping, Wang Sen, Upadhyaya Arun
Department of Nuclear Medicine, Tianjin Medical University General Hospital, Tianjin 300052, P.R. China.
Department of General Surgery, Tianjin Medical University General Hospital, Tianjin 300052, P.R. China.
Mol Clin Oncol. 2017 Jun;6(6):825-832. doi: 10.3892/mco.2017.1246. Epub 2017 May 8.
Ultrasound-guided core needle biopsy (US-CNB) of thyroid nodules is a relatively new technique used in surgical workup. However, no systematic review of this method has yet been performed. In the present meta-analysis, literature databases consisting of Cochrane Library, Medline, Embase, Scopus and Google Scholar were searched. Following eligibility assessments of the studies, quality appraisals were performed on the included studies using the Quality Assessment Tool for Diagnostic Accuracy Studies-2 method. The data were systematically analyzed by using Review Manager (version 5.3) and Meta-Disc (version 1.4). Eight investigations were included, and the study qualities were good. There were 1,621 nodules included in the final meta-analysis. The summary estimated that US-CNB had a sensitivity of 0.96 [95% confidence interval (CI)=0.94-0.97] and a specificity of 0.96 (95% CI=0.94-0.97). Positive and negative likelihood ratios, and the diagnostic odds ratio of US-CNB were 18.20 (95% CI=2.21-156.41), 0.08 (95% CI=0.02-0.27) and 250.60 (95% CI=19.11-3286.76), respectively. The area under the summary receiver operating characteristic curve was 0.979. Therefore, US-CNB may be considered as a reliable method in the assessment of thyroid nodules, and has an acceptable risk of complications.
甲状腺结节的超声引导下粗针穿刺活检（US-CNB）是外科检查中使用的一种相对较新的技术。然而，尚未对该方法进行系统评价。在本荟萃分析中，检索了包括Cochrane图书馆、Medline、Embase、Scopus和谷歌学术在内的文献数据库。在对研究进行纳入资格评估后，使用诊断准确性研究质量评估工具-2方法对纳入的研究进行质量评估。使用Review Manager（5.3版）和Meta-Disc（1.4版）对数据进行系统分析。纳入了八项研究，研究质量良好。最终的荟萃分析纳入了1621个结节。汇总估计US-CNB的敏感性为0.96[95%置信区间（CI）=0.94-0.97]，特异性为0.96（95%CI=0.94-0.97）。US-CNB的阳性和阴性似然比以及诊断比值比分别为18.20（95%CI=2.21-156.41）、0.08（95%CI=0.02-0.27）和250.60（95%CI=19.11-3286.76）。汇总受试者工作特征曲线下面积为0.979。因此，US-CNB可被视为评估甲状腺结节的可靠方法，且并发症风险可接受。
