Santiago Rayra P, Oliveira Rodrigo M, Soares Leonardo F, Figueiredo Camylla V B, Silva Denise Oliveira, Hurtado-Guerrero Ana F, Fiuza Luciana M, Guarda Caroline C, Adorno Elisângela V, Barbosa Cynara G, Gonçalves Marilda S
a Laboratório de Hematologia, Genética e Biologia Computacional , Instituto Gonçalo Moniz, Fundação Oswaldo Cruz , Bahia , Brasil.
b Departamento de Análises Clínicas e Toxicológicas , Universidade Federal da Bahia , Bahia , Brasil.
Hemoglobin. 2017 Mar;41(2):83-88. doi: 10.1080/03630269.2017.1321014. Epub 2017 Jun 7.
Brazilian Quilombolas are communities composed of African-derived populations that have their territories guaranteed by the Brazilian Constitution. The present study investigated the hemoglobin (Hb) variants among these population groups. This study was conducted in a total of 2843 individuals of Brazilian Quilombola communities of the Bahia, Pará, and Piauí states. All the participants had their Hb profiles evaluated. The Hb S (HBB: c.20A>T) variant was described in all the studied localities. However, the individuals in Bahia State had the highest frequency of the Hb C (HBB: c.19G>A) variant; individuals from Piauí State had a higher frequency of the Hb D-Punjab (HBB: c.364G>C) variant compared to the other states, and individuals from Pará State only carried the Hb S variant. The present study revealed a specific distribution of Hb variants that could represent different waves of African influence in these Brazilian populations.
巴西基隆波拉人社区由非洲裔人群组成，其领土受巴西宪法保障。本研究调查了这些人群中的血红蛋白（Hb）变体。该研究共对巴伊亚州、帕拉州和皮奥伊州的2843名巴西基隆波拉社区个体进行。所有参与者均接受了血红蛋白谱评估。在所研究的所有地区均发现了Hb S（HBB：c.20A>T）变体。然而，巴伊亚州个体的Hb C（HBB：c.19G>A）变体频率最高；与其他州相比，皮奥伊州个体的Hb D-旁遮普（HBB：c.364G>C）变体频率更高，而帕拉州个体仅携带Hb S变体。本研究揭示了Hb变体的特定分布情况，这可能代表了非洲对这些巴西人群不同阶段的影响。
