Ostrovskaia R U, Molodavkin G M
Biull Eksp Biol Med. 1985 Apr;99(4):448-50.
The influence of Ro 15-1788 and bicuculline on the action of GABA-positive drugs (muscimol), GABA cethyl ester, piracetam and depakine and benzodiazepine tranquilizers (diazepam, phenazepam) on motivated aggression has been studied. It has been shown that Ro 15-1788 which has a weak antiaggressive effect selectively antagonizes the anti-aggressive effect of tranquilizers but not that of GABA-positive drugs. Bicuculline antagonizes antiaggressive activity of the drugs of both types. The action of these antagonists on the effect of the drugs under study as regards the analgetic activity of morphine was also studied. It has been shown that Ro 15-1788 antagonizes the potentiation of morphine analgesia caused by diazepam. At the same time Ro 15-1788 does not influence morphine analgesia potentiated by muscimol. Bicuculline removes the potentiation of morphine analgesia caused both by diazepam and muscimol it is concluded that bicuculline-sensitive GABA receptors modulate the antiaggressive effect of benzodiazepines and their influence on the analgetic action of opiates.
研究了Ro 15 - 1788和荷包牡丹碱对GABA阳性药物（蝇蕈醇）、GABA乙酯、吡拉西坦和丙戊酸以及苯二氮䓬类镇静剂（地西泮、非那西泮）的激发性攻击行为作用的影响。结果表明，具有微弱抗攻击作用的Ro 15 - 1788选择性地拮抗镇静剂的抗攻击作用，但不拮抗GABA阳性药物的抗攻击作用。荷包牡丹碱拮抗这两种类型药物的抗攻击活性。还研究了这些拮抗剂对所研究药物在吗啡镇痛活性方面的作用。结果表明，Ro 15 - 1788拮抗地西泮引起的吗啡镇痛增强作用。同时，Ro 15 - 1788不影响蝇蕈醇增强的吗啡镇痛作用。荷包牡丹碱消除了地西泮和蝇蕈醇引起的吗啡镇痛增强作用。得出的结论是，对荷包牡丹碱敏感的GABA受体调节苯二氮䓬类药物的抗攻击作用及其对阿片类药物镇痛作用的影响。
