Soskel N T, Sandberg L B
Connect Tissue Res. 1985;13(2):127-33. doi: 10.3109/03008208509152391.
Lysyl oxidase, the enzyme responsible for mediating crosslink formation in collagen and elastin, requires copper for its activity. In this study, lysyl oxidase activity and insoluble elastin content were unchanged in lungs from copper-deficient hamsters compared to controls. The lack of dramatic diminution in lysyl oxidase activity in animals who demonstrate significant structural alterations in the lung suggests that other mechanisms in addition to inhibition of crosslink formation are operative in this model.
赖氨酰氧化酶是一种负责介导胶原蛋白和弹性蛋白交联形成的酶，其活性需要铜。在本研究中，与对照组相比，缺铜仓鼠肺中的赖氨酰氧化酶活性和不溶性弹性蛋白含量没有变化。在肺部出现明显结构改变的动物中，赖氨酰氧化酶活性没有显著降低，这表明除了抑制交联形成外，该模型中还存在其他作用机制。
