用于急性阑尾炎评估的低剂量CT方案优化：OPTICAP体模研究

LOW-DOSE CT PROTOCOL OPTIMIZATION FOR THE ASSESSMENT OF ACUTE APPENDICITIS: THE OPTICAP PHANTOM STUDY.

作者信息

Niiniviita Hannele, Salminen Paulina, Grönroos Juha M, Rinta-Kiikka Irina, Hurme Saija, Kiljunen Timo, Kulmala Jarmo, Teräs Mika, Sippola Suvi, Virtanen Johanna

机构信息

Department of Medical Physics, Turku University Hospital and University of Turku, Kiinamyllynkatu 4-8, FI-20520 Turku, Finland.

Department of Radiology, Medical Imaging Center of Southwest Finland, Turku University Hospital, Kiinamyllynkatu 4-8, FI-20520 Turku, Finland.

出版信息

Radiat Prot Dosimetry. 2018 Jan 1;178(1):20-28. doi: 10.1093/rpd/ncx070.

DOI:10.1093/rpd/ncx070

PMID:28591824

Abstract

UNLABELLED

The aim was to evaluate effects of voltage, noise input (NI) and iterative reconstruction (IR) on radiation dose and image quality in order to establish a contrast enhanced low-dose protocol for assessment of acute appendicitis. An anthropomorphic abdominal phantom mimicking contrast enhanced abdomen was scanned with 80, 100 and 120 kV, standard and strong IR and 11 NIs (66 protocols). A total of 14 test tubes of increasing iodine dilutions and one tube with an appendicolith were evaluated within the phantom. The dose, HUs, noise, contrast-to-noise ratio (CNR) and figure of merit (FOM) were determined. Visual quality scores were assessed by two readers. A clinically used voltage-IR combination (120 kV, standard IR) was used as a reference. Overall, 100 kV with standard IR (p = 0.002) and 80 kV with both IRs (p < 0.001) showed higher CNR than the reference, but noise was most pronounced at 80 kV (p < 0.001). The highest FOM was found in the 100 kV protocols (p < 0.001). The reference and 100 kV with standard IR had highest image quality scores, where the 100 kV protocol enabled a distinct dose reduction. Lowering the voltage seems to be a more favorable tool than IR changes in optimizing the dose in contrast enhanced abdominal CT.

TRIAL REGISTRATION

ClinicalTrials.gov number, NCT01022567.

摘要

未标注

目的是评估电压、噪声输入（NI）和迭代重建（IR）对辐射剂量和图像质量的影响，以建立用于评估急性阑尾炎的对比增强低剂量方案。使用模拟对比增强腹部的人体腹部模型，分别采用80、100和120 kV、标准和强力IR以及11种NI（共66种方案）进行扫描。在模型内共评估了14支碘稀释度递增的试管和1支含有阑尾结石的试管。测定了剂量、HU、噪声、对比噪声比（CNR）和品质因数（FOM）。由两名阅片者评估视觉质量评分。将临床使用的电压-IR组合（120 kV，标准IR）用作对照。总体而言，100 kV与标准IR（p = 0.002）以及80 kV与两种IR（p < 0.001）的CNR均高于对照，但80 kV时噪声最为明显（p < 0.001）。在100 kV方案中发现了最高的FOM（p < 0.001）。对照和100 kV与标准IR的图像质量评分最高，其中100 kV方案可实现显著的剂量降低。在优化对比增强腹部CT的剂量方面，降低电压似乎比改变IR是更有利的手段。