衰老相关tau星形胶质细胞病（ARTAG）的多中心评估
Multisite Assessment of Aging-Related Tau Astrogliopathy (ARTAG).
作者信息
Kovacs Gabor G, Xie Sharon X, Lee Edward B, Robinson John L, Caswell Carrie, Irwin David J, Toledo Jon B, Johnson Victoria E, Smith Douglas H, Alafuzoff Irina, Attems Johannes, Bencze Janos, Bieniek Kevin F, Bigio Eileen H, Bodi Istvan, Budka Herbert, Dickson Dennis W, Dugger Brittany N, Duyckaerts Charles, Ferrer Isidro, Forrest Shelley L, Gelpi Ellen, Gentleman Stephen M, Giaccone Giorgio, Grinberg Lea T, Halliday Glenda M, Hatanpaa Kimmo J, Hof Patrick R, Hofer Monika, Hortobágyi Tibor, Ironside James W, King Andrew, Kofler Julia, Kövari Enikö, Kril Jillian J, Love Seth, Mackenzie Ian R, Mao Qinwen, Matej Radoslav, McLean Catriona, Munoz David G, Murray Melissa E, Neltner Janna, Nelson Peter T, Ritchie Diane, Rodriguez Roberta D, Rohan Zdenek, Rozemuller Annemieke, Sakai Kenji, Schultz Christian, Seilhean Danielle, Smith Vanessa, Tacik Pawel, Takahashi Hitoshi, Takao Masaki, Rudolf Thal Dietmar, Weis Serge, Wharton Stephen B, White Charles L, Woulfe John M, Yamada Masahito, Trojanowski John Q
机构信息
Institute of Neurology, Medical University of Vienna, Vienna, Austria; Center for Neurodegenerative Disease Research, Institute on Aging and Department of Pathology and Laboratory Medicine of the Perelman School of Medicine at the University of Pennsylvania; and Department of Biostatistics and Epidemiology; and Department of Neurosurgery, Center for Brain Injury and Repair, University of Pennsylvania, Philadelphia, Pennsylvania; Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden; Institute of Neuroscience, Newcastle University, Newcastle upon Tyne, UK; Department of Neuropathology, Institute of Pathology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary; Department of Neuroscience, Mayo Clinic, Jacksonville, Florida; Northwestern University Feinberg School of Medicine, Northwestern ADC Neuropathology Core, Chicago, Illinois; Clinical Neuropathology, King's College Hospital and London Neurodegenerative Brain Bank, London, UK; Institute of Neuropathology, University Hospital Zurich, Zurich, Switzerland; University of California San Francisco, Institute for Neurodegenerative Diseases, San Francisco, California; Neuropathology Department, Hôpital de La Salpetrière, AP-HP, UPMC-Sorbonne-University, Paris, France; Institute of Neuropathology, Bellvitge University Hospital, University of Barcelona, CIBERNED, Hospitalet de Llobregat, Barcelona, Spain; Discipline of Pathology, Sydney Medical School, The University of Sydney, Sydney, Australia; Neurological Tissue Bank of the Biobank-Hospital Clinic-IDIBAPS, Institut d'Investigacions Biomediques Pi i, Barcelona, Spain; Department of Medicine, Imperial College London, London, UK; IRCCS Foundation "Carlo Besta" Neurological Institute, Milan, Italy; Memory and Aging Center, Department of Neurology, University of California, San Francisco, California; Department of Pathology, University of Sao Paulo Medical School, LIM, São Paulo, Brazil; Brain & Mind Centre, Sydney Medical School, The University of Sydney, and UNSW Medicine & NeuRA, Sydney, Australia; Department of Pathology, University of Texas Southwestern Medical Center, Dallas, Texas; Fishberg Department of Neuroscience, Friedman Brain Institute, and Ronald M. Loeb Center for Alzheimer's Disease, Icahn School of Medicine at Mount Sinai, New York, New York; Department of Neuropathology, John Radcliffe Hospital, Oxford, UK; Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK; Department of Pathology, University of Pittsburgh, Pittsburgh, Pennsylvania; Department of Mental Health and Psychiatry, University Hospitals and University of Geneva School of Medicine, Geneva, Switzerland; Institute of Clinical Neurosciences, University of Bristol, Learning & Research Level 2, Southmead Hospital, Bristol, UK; Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, Canada; Department of Pathology and Molecular Medicine, Thomayer Hospital, Prague, Czech Republic; Department of Pathology, First Medical Faculty, Charles University, Prague, Czech Republic; Department of Anatomical Pathology, Alfred Hospital , Prahran, Victoria, Australia; Division of Pathology, St. Michael's Hospital, Toronto, Ontario, Canada; Department of Pathology and Sanders-Brown Center on Aging, University of Kentucky, Lexington, Kentucky; Physiopathology in Aging Lab/Brazilian Aging Brain Study Group-LIM22, University of Sao Paulo Medical School, Sao Paulo, Brazil; Behavioral and Cognitive Neurology Unit, Department of Neurology, University of São Paulo , São Paulo, Brazil; Netherlands Brainbank, Amsterdam and Department of Pathology, VU University Medical Center, Amsterdam, The Netherlands; Department of Neurology and Neurobiology of Aging, Kanazawa University Graduate School of Medical Sciences, Kanazawa, Japan; Institute of Neuroanatomy, Centre for Biomedicine and Medical Technology Mannheim, Medical Faculty Mannheim, Heidelberg University, Heidelberg, Germany; Department of Neurodegenerative Diseases and Gerontopsychiatry at the University of Bonn Medical Center, Bonn, Germany; Department of Pathology, Brain Research Institute, Niigata University, Niigata, Japan; Department of Neurology, Saitama Medical University International Medical Center, Saitama, Japan; Department of Neuroscience, Katholieke Universiteit-Leuven; and Department of Pathology, Universitaire Ziekenhuizen-Leuven, Leuven, Belgium; Laboratory of Neuropathology, Department of Pathology and Neuropathology, Kepler University Hospital, Medical School, Johannes Kepler University, Linz, Austria; Sheffield Institute for Translational Neuroscience, University of Sheffield, Sheffield, UK; and Department of Pathology and Laboratory Medicine, Centre for Cancer Therapeutics, Ottawa Hospital Research Institute, University of Ottawa, Ontario, Canada.
出版信息
J Neuropathol Exp Neurol. 2017 Jul 1;76(7):605-619. doi: 10.1093/jnen/nlx041.
Aging-related tau astrogliopathy (ARTAG) is a recently introduced terminology. To facilitate the consistent identification of ARTAG and to distinguish it from astroglial tau pathologies observed in the primary frontotemporal lobar degeneration tauopathies we evaluated how consistently neuropathologists recognize (1) different astroglial tau immunoreactivities, including those of ARTAG and those associated with primary tauopathies (Study 1); (2) ARTAG types (Study 2A); and (3) ARTAG severity (Study 2B). Microphotographs and scanned sections immunostained for phosphorylated tau (AT8) were made available for download and preview. Percentage of agreement and kappa values with 95% confidence interval (CI) were calculated for each evaluation. The overall agreement for Study 1 was >60% with a kappa value of 0.55 (95% CI 0.433-0.645). Moderate agreement (>90%, kappa 0.48, 95% CI 0.457-0.900) was reached in Study 2A for the identification of ARTAG pathology for each ARTAG subtype (kappa 0.37-0.72), whereas fair agreement (kappa 0.40, 95% CI 0.341-0.445) was reached for the evaluation of ARTAG severity. The overall assessment of ARTAG showed moderate agreement (kappa 0.60, 95% CI 0.534-0.653) among raters. Our study supports the application of the current harmonized evaluation strategy for ARTAG with a slight modification of the evaluation of its severity.
衰老相关的tau星形胶质细胞病（ARTAG）是一个最近引入的术语。为了便于对ARTAG进行一致的识别，并将其与在原发性额颞叶痴呆tau蛋白病中观察到的星形胶质细胞tau病变相区分，我们评估了神经病理学家在以下方面的识别一致性：（1）不同的星形胶质细胞tau免疫反应性，包括ARTAG的免疫反应性和与原发性tau蛋白病相关的免疫反应性（研究1）；（2）ARTAG类型（研究2A）；以及（3）ARTAG严重程度（研究2B）。提供了磷酸化tau（AT8）免疫染色的显微照片和扫描切片以供下载和预览。对每次评估计算一致性百分比和95%置信区间（CI）的kappa值。研究1的总体一致性>60%，kappa值为0.55（95%CI 0.433 - 0.645）。在研究2A中，对于每种ARTAG亚型的ARTAG病理识别达到了中度一致性（>90%，kappa 0.48，95%CI 0.457 - 0.900）（kappa 0.37 - 0.72），而对于ARTAG严重程度的评估达到了中等一致性（kappa 0.40，95%CI 0.341 - 0.445）。评估者之间对ARTAG的总体评估显示出中等一致性（kappa 0.60，95%CI 0.534 - 0.653）。我们的研究支持对ARTAG采用当前统一的评估策略，并对其严重程度评估进行轻微修改。
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