Medgett I C
Eur J Pharmacol. 1985 Feb 5;108(3):281-7. doi: 10.1016/0014-2999(85)90450-9.
Proximal and distal segments of the tail artery were taken from normotensive Sprague-Dawley rats. Field stimulation (0.3-30 Hz) of periarterial sympathetic nerves elicited vasoconstrictor responses which were antagonized by prazosin (0.1-10 nM) to a much lesser extent in distal than in proximal segments. The selective alpha 2-adrenoceptor antagonist idazoxan (100 nM) alone had little effect in either segment; however in combination with prazosin vasoconstrictor responses were markedly reduced in distal segments. It is concluded that postjunctional alpha 2-adrenoceptors substantially mediate sympathetic vasoconstriction in distal segments of Sprague-Dawley rat tail artery and that this in vitro preparation may be a useful model for elucidating and extending data obtained in vivo in the human forearm circulation (Van Brummelen et al., 1983).
从正常血压的斯普拉格-道利大鼠身上获取尾动脉的近端和远端节段。对动脉周围交感神经进行场刺激（0.3 - 30赫兹）会引发血管收缩反应，哌唑嗪（0.1 - 10纳摩尔）对这种反应的拮抗作用在远端节段比在近端节段小得多。选择性α2肾上腺素能受体拮抗剂咪唑克生（100纳摩尔）单独使用时在两个节段中作用都很小；然而，与哌唑嗪联合使用时，远端节段的血管收缩反应明显降低。得出的结论是，节后α2肾上腺素能受体在很大程度上介导了斯普拉格-道利大鼠尾动脉远端节段的交感神经血管收缩，并且这种体外制备方法可能是一种有用的模型，用于阐明和扩展在人体前臂循环中体内获得的数据（范布鲁梅伦等人，1983年）。
