COX5B 高表达与乳腺癌预后不良相关。
High expression of COX5B is associated with poor prognosis in breast cancer.
机构信息
Department of Breast Surgery, Key Laboratory of Breast Cancer in Shanghai, Collaborative Innovation Center of Cancer Medicine, Fudan University Shanghai Cancer Center, Shanghai 200032, China.
Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China.
出版信息
Future Oncol. 2017 Aug;13(19):1711-1719. doi: 10.2217/fon-2017-0058. Epub 2017 Jun 8.
BACKGROUND
Cytochrome c oxidase subunit VB (COX5B), a subunit of mammalian COX, takes roles in COX assembling and functions. Online database predicts high COX5B transcription may be associated with worse disease-free survival (DFS). However, the clinical implications of COX5B in breast cancer remain unclear.
METHODS
We carried out immunohistochemistry on tissue microarrays of 244 patients with invasive ductal breast carcinoma to detected COX5B expression.
RESULTS
Our results suggest that COX5B protein level might be associated with tumor size. COX5B overexpression indicated a worse DFS (p < 0.05) in breast cancer. Furthermore, high COX5B expression may act as an independent factor for worse DFS in breast cancer.
CONCLUSIONS
Cumulatively, our findings suggest that COX5B might serve as an important prognostic factor for breast cancer.
背景
细胞色素 c 氧化酶亚基 VB（COX5B）是哺乳动物 COX 的一个亚基，在 COX 的组装和功能中发挥作用。在线数据库预测，高 COX5B 转录可能与无病生存期（DFS）较差相关。然而，COX5B 在乳腺癌中的临床意义仍不清楚。
方法
我们对 244 例浸润性导管乳腺癌患者的组织微阵列进行了免疫组织化学检测，以检测 COX5B 的表达。
结果
我们的结果表明 COX5B 蛋白水平可能与肿瘤大小有关。COX5B 过表达提示乳腺癌的 DFS 较差（p<0.05）。此外，高 COX5B 表达可能是乳腺癌 DFS 较差的独立因素。
结论
综上所述，我们的研究结果表明 COX5B 可能是乳腺癌的一个重要预后因素。
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