Kritsaneepaiboon Supika, Ina Natee, Chotsampancharoen Thirachit, Roymanee Supaporn, Cheewatanakornkul Sirichai
1 Department of Radiology, Faculty of Medicine, Prince of Songkla University, Hat Yai, Thailand.
2 Department of Pediatrics, Faculty of Medicine, Prince of Songkla University, Hat Yai, Thailand.
Acta Radiol. 2018 Mar;59(3):355-362. doi: 10.1177/0284185117715285. Epub 2017 Jun 7.
Background Cardiac and liver iron assessment using magnetic resonance imaging (MRI) is non-invasive and used as a preclinical "endpoint" in asymptomatic patients and for serial iron measurements in iron-overloaded patients. Purpose To compare iron measurements between hepatic and myocardial T2* and T2 at 1.5T and 3T MRI in normal and iron-overloaded patients. Material and Methods The T2 and T2* values from the regions of interest (ROIs) at mid-left ventricle and mid-hepatic slices were evaluated by 1.5T and 3T MRI scans for healthy and iron-overloaded patients. Results For iron-overloaded patients, the myocardial T2 (1.5T) and myocardial T2 (3T) values were 60.3 ms (range = 56.2-64.8 ms) and 55 ms (range = 51.6-60.1 ms) (ρ = 0.3679) while the myocardial T2* (3T) 20.5 ms (range = 18.4-25.9 ms) was shorter than the myocardial T2* (1.5T) 35.9 ms (range = 31.4-39.5 ms) (ρ = 0.6454). The hepatic T2 at 1.5T and 3T were 19.1 ms (range = 14.8-27.9 ms) and 15.5 ms (14.6-20.4 ms) (ρ = 0.9444) and the hepatic T2* at 1.5T and 3T were 2.7 ms (range = 1.8-5.6 ms) and 1.8 ms (range = 1.1-2.9 ms) (ρ = 0.9826). The line of best fit exhibiting the linearity of the hepatic T2* (1.5T) and hepatic T2* (3T) had a slope of 2 and an intercept of -0.387 ms (R = 0.984). Conclusion Our study found myocardial T2 (1.5T) nearly equal to T2 (3T) with myocardial T2* (3T) 1.75 shorter than myocardial T2* (1.5T). The relationship of hepatic T2* (1.5T) and hepatic T2* (3T) was linear with T2* (1.5T) approximately double to T2* (3T) in iron-overloaded patients. This linear relationship between hepatic T2* (1.5T) and hepatic T2 (3T) could be an alternative method for estimating liver iron concentration (LIC) from 3T.
使用磁共振成像（MRI）评估心脏和肝脏铁含量是非侵入性的，可作为无症状患者的临床前“终点”以及铁过载患者的系列铁测量方法。目的：比较正常和铁过载患者在1.5T和3T MRI下肝脏和心肌的T2及T2铁测量值。材料与方法：通过1.5T和3T MRI扫描评估健康和铁过载患者左心室中部和肝脏中部切片感兴趣区域（ROI）的T2和T2值。结果：对于铁过载患者，心肌T2（1.5T）和心肌T2（3T）值分别为60.3毫秒（范围=56.2 - 64.8毫秒）和55毫秒（范围=51.6 - 60.1毫秒）（ρ=0.3679），而心肌T2*（3T）为20.5毫秒（范围=18.4 - 25.9毫秒）短于心肌T2*（1.5T）的35.9毫秒（范围=31.4 - 39.5毫秒）（ρ=0.6454）。1.5T和3T时肝脏T2分别为19.1毫秒（范围=14.8 - 27.9毫秒）和第15.5毫秒（14.6 - 20.4毫秒）（ρ=0.9444），1.5T和3T时肝脏T2分别为2.7毫秒（范围=1.8 - 5.6毫秒）和1.8毫秒（范围=1.1 - 2.9毫秒）（ρ=0.9826）。显示肝脏T2（1.5T）和肝脏T2*（3T）线性关系的最佳拟合线斜率为2，截距为 - 0.387毫秒（R = 0.984）。结论：我们的研究发现心肌T2（1.5T）几乎等于T2（3T），心肌T2*（3T）比心肌T2*（1.5T）短1.75倍。在铁过载患者中，肝脏T2*（1.5T）和肝脏T2*（3T）的关系呈线性，T2*（1.5T）约为T2*（3T）的两倍。肝脏T2*（1.5T）和肝脏T2*（3T）之间的这种线性关系可能是从3T估计肝脏铁浓度（LIC）的替代方法。
