Faigle J W, Stierlin H, Mory H, Winkler T, Kriemler H P
Experientia. 1985 Apr 15;41(4):476-8. doi: 10.1007/BF01966155.
Indoxyl derivatives were detected as minor products among the urinary metabolites of two trial drugs, a benzodiazepine (GP 55 129) and a benzophenone (CGP 11 952). Their structures were elucidated by NMR and mass spectroscopy. Presumably, metabolites containing potential aldehyde functions react spontaneously with endogenous indoxyl. Such derivatives have not hitherto been encountered in drug metabolism.
在两种试验药物（一种苯二氮䓬类药物（GP 55 129）和一种二苯甲酮类药物（CGP 11 952））的尿液代谢产物中，吲哚酚衍生物被检测为次要产物。通过核磁共振（NMR）和质谱对其结构进行了阐明。据推测，含有潜在醛基功能的代谢产物会与内源性吲哚酚自发反应。此类衍生物在药物代谢中尚未被发现过。
