Estañ L, Morales-Olivas F J, Rubio E, Esplugues J
Gynecol Obstet Invest. 1985;19(1):53-6. doi: 10.1159/000299008.
In the present study the effect of methoxamine and its modification by several adrenergic antagonists is described in the isolated oestrogenized rat uterus. Methoxamine produced a dose-related increase in uterine activity, prazosin produced a rightward displacement of the dose-response curve of methoxamine reaching the same maximal effect. Yohimbine abolished the contractile response to methoxamine. propranolol or reserpine failed to modify the effect of methoxamine. Pretreatment with reserpine abolished the inhibitory effect of yohimbine. These results suggest the presence of excitatory alpha-adrenoceptors in the rat uterus.
在本研究中，描述了甲氧明及其经几种肾上腺素能拮抗剂修饰后的作用，实验对象是雌激素化的离体大鼠子宫。甲氧明使子宫活动呈剂量相关增加，哌唑嗪使甲氧明的剂量-反应曲线右移，最大效应相同。育亨宾消除了对甲氧明的收缩反应。普萘洛尔或利血平未能改变甲氧明的作用。利血平预处理消除了育亨宾的抑制作用。这些结果提示大鼠子宫中存在兴奋性α-肾上腺素能受体。
