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院外心脏骤停的场景时间间隔与良好的神经功能恢复

Scene time interval and good neurological recovery in out-of-hospital cardiac arrest.

作者信息

Kim Ki Hong, Shin Sang Do, Song Kyoung Jun, Ro Young Sun, Kim Yu Jin, Hong Ki Jeong, Jeong Joo

机构信息

Department of Emergency Medicine, Seoul National University Hospital, Seoul, Republic of Korea.

Department of Emergency Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea.

出版信息

Am J Emerg Med. 2017 Nov;35(11):1682-1690. doi: 10.1016/j.ajem.2017.05.049. Epub 2017 May 29.

DOI:10.1016/j.ajem.2017.05.049
PMID:28592372
Abstract

OBJECTIVES

It is unclear whether scene time interval (STI) is associated with better neurological recovery in the emergency medical service (EMS) system with intermediate service level.

METHODS

Adult out-of-hospital cardiac arrest (OHCA) patients with presumed cardiac etiology (2012 to 2014) were analyzed, excluding patients not-resuscitated, occurred in ambulance/medical/nursing facility, unknown STI or extremely longer STI (>60 min), and unknown outcomes. STI was classified into short (0.0-3.9 min), middle (4.0-7.9 min), long (8.0-11.9 min), and very-long (12.0-59.9 min), respectively. The end point was a good cerebral performance category (CPC) 1 or 2. Multivariable logistic regression by STI group (reference=short) was performed to calculate adjusted odds ratios (AORs) with 95% confidence intervals (95% CIs) for outcomes with or without interaction term (STI∗prehospital return of spontaneous circulation, (PROSC)).

RESULTS

Of 79,832 OHCA patients, 41,054 cases were analyzed; good CPC in the short (3.0%), middle (3.2%), long (3.0%), and very-long (2.9%) STI groups were similar, respectively (p=0.55). The AORs (95% CI) for good CPC in the final model without interaction term were 0.74 (0.58-0.95) for the middle, 0.51 (0.39-0.67) for the long, and 0.45 (0.33-0.61) for the very-long STI group (reference=short STI). The AORs in PROSC group were 1.18 (0.97-1.44) for middle STI group, 0.72 (0.57-0.92) for long group, and 0.56 (0.42-0.77) for very-long group. The AORs in non-PROSC group were 1.22 (1.06-1.40) for middle STI group, 0.82 (0.70-0.96) for long group, and 0.70 (0.57-0.85) for very-long group.

CONCLUSION

The middle STI (4-7min) was associated with the highest odds of neurological recovery for patients who could not be restored in the field. The STI may be a clinically useful predictor of good neurology outcome in victims of cardiac arrest.

摘要

目的

尚不清楚在中级服务水平的紧急医疗服务(EMS)系统中,现场时间间隔(STI)是否与更好的神经功能恢复相关。

方法

对2012年至2014年推测为心脏病因的成年院外心脏骤停(OHCA)患者进行分析,排除未复苏患者、发生在救护车/医疗/护理机构的患者、STI未知或极长(>60分钟)的患者以及结局未知的患者。STI分别分为短(0.0 - 3.9分钟)、中(4.0 - 7.9分钟)、长(8.0 - 11.9分钟)和极长(12.0 - 59.9分钟)。终点是良好的脑功能类别(CPC)1或2。按STI组(参照=短)进行多变量逻辑回归,计算有或无交互项(STI*院前自主循环恢复,(PROSC))的结局的调整优势比(AOR)及95%置信区间(95%CI)。

结果

在79,832例OHCA患者中,分析了41,054例;短(3.0%)、中(3.2%)、长(3.0%)和极长(2.9%)STI组的良好CPC相似(p = 0.55)。在无交互项的最终模型中,中、长和极长STI组(参照=短STI组)良好CPC的AOR(95%CI)分别为0.74(0.58 - 0.95)、0.51(0.39 - 0.67)和0.45(0.33 - 0.61)。PROSC组中,中STI组的AOR为1.18(0.97 - 1.44),长组为0.72(0.57 - 0.92),极长组为0.56(0.42 - 0.77)。非PROSC组中,中STI组的AOR为1.22(1.06 - 1.40),长组为0.82(0.70 - 0.96),极长组为0.70(0.57 - 0.85)。

结论

对于现场无法恢复自主循环的患者,中STI(4 - 7分钟)与神经功能恢复的最高几率相关。STI可能是心脏骤停受害者良好神经功能结局的临床有用预测指标。

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