Brindley G W, Cofield R H
Foot Ankle. 1985 Mar-Apr;5(5):245-50. doi: 10.1177/107110078500500505.
Forty-one patients with 42 involved feet received local care for neuropathic foot disease. Thirty-one patients had ulcers (nine with associated fractures), and 10 did not (eight with fracture and two with severe ligamentous injury). Patients were examined at least 1 year after initiation of treatment, and follow-up averaged 3 years (range, 1 to 9). Treatment included ulcer cleansing, debridement, local bone excision, molded plaster casts, and antibiotics for patients with significant infection. Most patients used special shoes. Of the 42 involved extremities, 39 (93%) healed with treatment, 21 extremities (50%) remained healed at follow-up examination, and 16 patients (39%) continue to have difficulty with recurrent foot ulceration or osteoarthropathy. Thirty-nine patients (95%) have avoided the need for a major amputation.
41例患有42只受累足部的患者接受了神经性足部疾病的局部治疗。31例患者有溃疡（9例伴有相关骨折），10例没有（8例骨折，2例严重韧带损伤）。患者在开始治疗后至少1年接受检查，随访平均3年（范围1至9年）。治疗包括溃疡清创、局部骨切除、定制石膏绷带，以及对有严重感染的患者使用抗生素。大多数患者使用特制鞋子。在42只受累肢体中，39只（93%）经治疗后愈合，21只肢体（50%）在随访检查时仍保持愈合状态，16例患者（39%）仍有复发性足部溃疡或骨关节炎问题。39例患者（95%）避免了大截肢的需要。
